Abstract
A new antibiotic, trichostatin, was isolated from the metabolites of strains of Streptomyces hygroscopicus. It is active against trichophytons and some fungi. The structure was determined to be a derivative of a primary hydroxamic acid by chemical and spectroscopic evidences.
MeSH terms
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Acetylation
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Antifungal Agents* / biosynthesis
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Antifungal Agents* / isolation & purification
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Antifungal Agents* / pharmacology
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Chemical Phenomena
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Chemistry
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Fungi / drug effects
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Hydroxamic Acids / analysis
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Hydroxamic Acids / isolation & purification
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Streptomyces / metabolism
Substances
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Antifungal Agents
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Hydroxamic Acids