Abstract
The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cholesterol, Dietary
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DNA-Binding Proteins
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Dimerization
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Humans
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Liver X Receptors
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Mice
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Mice, Knockout
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Orphan Nuclear Receptors
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Receptors, Cytoplasmic and Nuclear / chemistry*
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Receptors, Cytoplasmic and Nuclear / deficiency
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Receptors, Retinoic Acid / chemistry
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Receptors, Retinoic Acid / metabolism
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Retinoid X Receptors
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Sterols / metabolism*
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Transcription Factors / chemistry
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Transcription Factors / metabolism*
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Transcription, Genetic*
Substances
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Cholesterol, Dietary
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DNA-Binding Proteins
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Liver X Receptors
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Orphan Nuclear Receptors
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Receptors, Cytoplasmic and Nuclear
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Sterols
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Transcription Factors