Abstract
Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.
MeSH terms
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Animals
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Apoptosis Regulatory Proteins
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Apoptosis*
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GPI-Linked Proteins
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Humans
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Membrane Glycoproteins / physiology*
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RNA, Messenger / analysis
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor / physiology*
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Receptors, Tumor Necrosis Factor, Member 10c
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TNF-Related Apoptosis-Inducing Ligand
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Tumor Cells, Cultured
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha / physiology*
Substances
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Apoptosis Regulatory Proteins
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GPI-Linked Proteins
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Membrane Glycoproteins
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RNA, Messenger
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Member 10c
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TNF-Related Apoptosis-Inducing Ligand
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TNFRSF10A protein, human
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TNFRSF10B protein, human
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TNFRSF10C protein, human
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TNFSF10 protein, human
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha