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Page 1
The disposition and metabolism of zibotentan (ZD4054): an oral-specific endothelin A receptor antagonist in mice, rats and dogs.
Xenobiotica. 2011 Sep;41(9):784-96. doi: 10.3109/00498254.2011.562565. Epub 2011 Jun 10.
Xenobiotica. 2011.
PMID: 21657967
Disposition and metabolism of the specific endothelin A receptor antagonist zibotentan (ZD4054) in healthy volunteers.
Clarkson-Jones JA, Kenyon AS, Kemp J, Lenz EM, Oliver SD, Swaisland H.
Clarkson-Jones JA, et al.
Xenobiotica. 2012 Apr;42(4):363-71. doi: 10.3109/00498254.2011.624204. Epub 2011 Oct 20.
Xenobiotica. 2012.
PMID: 22014279
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Disposition and metabolism of the colchicine derivative [14C]-ZD6126 in rat and dog.
Partridge EA, D'Souza RA, Lenz EM, Smith SM, Clarkson-Jones J, Roberts DW.
Partridge EA, et al. Among authors: clarkson jones j.
Xenobiotica. 2008 Apr;38(4):399-421. doi: 10.1080/00498250701861742.
Xenobiotica. 2008.
PMID: 18340564
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Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential.
Vishwanathan K, Mair S, Gupta A, Atherton J, Clarkson-Jones J, Edeki T, Das S.
Vishwanathan K, et al. Among authors: clarkson jones j.
Drug Metab Dispos. 2014 May;42(5):932-42. doi: 10.1124/dmd.113.055335. Epub 2014 Mar 10.
Drug Metab Dispos. 2014.
PMID: 24616266
Clinical Trial.
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The metabolism of [14C]-zibotentan (ZD4054) in rat, dog and human, the loss of the radiolabel and the identification of an anomalous peak, derived from the animal feed.
Lenz EM, Kenyon A, Martin S, Temesi D, Clarkson-Jones J, Tomkinson H.
Lenz EM, et al. Among authors: clarkson jones j.
J Pharm Biomed Anal. 2011 Jun 1;55(3):500-17. doi: 10.1016/j.jpba.2011.02.005. Epub 2011 Mar 12.
J Pharm Biomed Anal. 2011.
PMID: 21398067
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Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man.
McKillop D, Hutchison M, Partridge EA, Bushby N, Cooper CM, Clarkson-Jones JA, Herron W, Swaisland HC.
McKillop D, et al. Among authors: clarkson jones ja.
Xenobiotica. 2004 Oct;34(10):917-34. doi: 10.1080/00498250400009171.
Xenobiotica. 2004.
PMID: 15764411
Clinical Trial.
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Evaluation of the use of UPLC-TOFMS with simultaneous [14C]-radioflow detection for drug metabolite profiling: application to propranolol metabolites in rat urine.
Athersuch TJ, Sison RL, Kenyon AS, Clarkson-Jones JA, Wilson ID.
Athersuch TJ, et al. Among authors: clarkson jones ja.
J Pharm Biomed Anal. 2008 Sep 10;48(1):151-7. doi: 10.1016/j.jpba.2008.05.003. Epub 2008 May 14.
J Pharm Biomed Anal. 2008.
PMID: 18571352
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