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Page 1
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
Xenobiotica. 2011 Dec;41(12):1044-55. doi: 10.3109/00498254.2011.604743. Epub 2011 Aug 23.
Xenobiotica. 2011.
PMID: 21859392
Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305.
Potęga A, Fedejko-Kap B, Mazerska Z.
Potęga A, et al. Among authors: fedejko kap b.
Xenobiotica. 2016 Dec;46(12):1056-1065. doi: 10.3109/00498254.2016.1147623. Epub 2016 Feb 29.
Xenobiotica. 2016.
PMID: 26928326
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Potęga A, Fedejko-Kap B, Mazerska Z.
Potęga A, et al. Among authors: fedejko kap b.
Pharmacol Rep. 2016 Aug;68(4):663-70. doi: 10.1016/j.pharep.2016.02.003. Epub 2016 Mar 16.
Pharmacol Rep. 2016.
PMID: 27110874
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Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Fedejko-Kap B, Bratton SM, Finel M, Radominska-Pandya A, Mazerska Z.
Fedejko-Kap B, et al.
Drug Metab Dispos. 2012 Sep;40(9):1736-43. doi: 10.1124/dmd.112.045401. Epub 2012 Jun 1.
Drug Metab Dispos. 2012.
PMID: 22659092
Free PMC article.
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
Pawlowska M, Chu R, Fedejko-Kap B, Augustin E, Mazerska Z, Radominska-Pandya A, Chambers TC.
Pawlowska M, et al. Among authors: fedejko kap b.
Drug Metab Dispos. 2013 Feb;41(2):414-21. doi: 10.1124/dmd.112.047811. Epub 2012 Nov 16.
Drug Metab Dispos. 2013.
PMID: 23160818
Free PMC article.
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