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Disposition of cisapride appears to be influenced by P-glycoprotein in the mouse.
Clin Pharmacol Ther. 2005 Mar;77(3):225-6. doi: 10.1016/j.clpt.2004.10.009.
Clin Pharmacol Ther. 2005.
PMID: 15735616
No abstract available.
Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.
Kalgutkar AS, Frederick KS, Hatch HL, Ambler CM, Perry DA, Garigipati RS, Chang GC, Lefker BA, Clark RW, Morehouse LA, Francone O, Hu X.
Kalgutkar AS, et al. Among authors: hatch hl.
Xenobiotica. 2014 Jul;44(7):591-605. doi: 10.3109/00498254.2013.874611. Epub 2013 Dec 31.
Xenobiotica. 2014.
PMID: 24380613
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Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human.
Kalgutkar AS, Feng B, Nguyen HT, Frederick KS, Campbell SD, Hatch HL, Bi YA, Kazolias DC, Davidson RE, Mireles RJ, Duignan DB, Choo EF, Zhao SX.
Kalgutkar AS, et al. Among authors: hatch hl.
Drug Metab Dispos. 2007 Nov;35(11):2111-8. doi: 10.1124/dmd.107.016162. Epub 2007 Aug 8.
Drug Metab Dispos. 2007.
PMID: 17686907
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Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
Kalgutkar AS, et al. Among authors: hatch hl.
Biopharm Drug Dispos. 2006 Nov;27(8):371-86. doi: 10.1002/bdd.520.
Biopharm Drug Dispos. 2006.
PMID: 16944451
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