Synthesis of a new fluoro-Wang resin for solid-phase reaction monitoring by 19F NMR spectroscopy

J M Salvino; S Patel; M Drew; P Krowlikowski; E Orton; N V Kumar; T Caulfield; R Labaudiniere

doi:10.1021/cc000076r

Synthesis of a new fluoro-Wang resin for solid-phase reaction monitoring by 19F NMR spectroscopy

J Comb Chem. 2001 Mar-Apr;3(2):177-80. doi: 10.1021/cc000076r.

Authors

J M Salvino¹, S Patel, M Drew, P Krowlikowski, E Orton, N V Kumar, T Caulfield, R Labaudiniere

Affiliation

¹ Lead Discovery Department, Rhone Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA.

PMID: 11300858
DOI: 10.1021/cc000076r

Abstract

A new fluoro-Wang resin is presented which facilitates solid-phase reaction monitoring using 19F NMR. The resin is easily synthesized and amenable to scale-up. The method described herein compliments single-bead FT-IR and 13C NMR techniques. This method allows monitoring of solid-phase reactions even if the resin bound intermediate is unstable to the cleavage conditions. In addition, this is a useful tool to study reaction kinetics on the solid phase.