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2004 1
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Page 1
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. Brotherton-Pleiss C, et al. Among authors: lopez tapia f. J Med Chem. 2021 Jan 14;64(1):695-710. doi: 10.1021/acs.jmedchem.0c01705. Epub 2020 Dec 22. J Med Chem. 2021. PMID: 33352047 Free PMC article.
Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.
Lopez-Tapia F, Walker KA, Brotherton-Pleiss C, Caroon J, Nitzan D, Lowrie L, Gleason S, Zhao SH, Berger J, Cockayne D, Phippard D, Suttmann R, Fitch WL, Bourdet D, Rege P, Huang X, Broadbent S, Dvorak C, Zhu J, Wagner P, Padilla F, Loe B, Jahangir A, Alker A. Lopez-Tapia F, et al. J Med Chem. 2015 Nov 12;58(21):8413-26. doi: 10.1021/acs.jmedchem.5b00365. Epub 2015 Nov 2. J Med Chem. 2015. PMID: 26460788
Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo.
Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, Nakamura K, Chen W, Chen Y, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Kershaw KM, Celeridad M, Pan S, Limpert AS, Sheffler DJ, Cosford NDP, Shiao SL, Tius MA, Lopez-Tapia F, Turkson J. Yue P, et al. Among authors: lopez tapia f. Cancer Lett. 2022 May 28;534:215613. doi: 10.1016/j.canlet.2022.215613. Epub 2022 Mar 9. Cancer Lett. 2022. PMID: 35276290 Free PMC article.
Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3.
Chen Y, Zhai N, Zhu Y, Yue P, Verma N, Brotherton-Pleiss C, Fu W, Nakamura K, Chen W, Kawakami J, Murali R, Tius MA, Lopez-Tapia F, Turkson J. Chen Y, et al. Among authors: lopez tapia f. Bioorg Med Chem Lett. 2024 Jan 1;97:129565. doi: 10.1016/j.bmcl.2023.129565. Epub 2023 Nov 24. Bioorg Med Chem Lett. 2024. PMID: 38008341 Free article. No abstract available.
Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.
Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J. Lopez-Tapia F, et al. ACS Med Chem Lett. 2018 Feb 16;9(3):250-255. doi: 10.1021/acsmedchemlett.7b00544. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541369 Free PMC article.
Identification of glutathione-derived metabolites from an IP receptor antagonist.
Fitch WL, Berry PW, Tu Y, Tabatabaei A, Lowrie L, Lopez-Tapia F, Liu Y, Nitzan D, Masjedizadeh MR, Varadarajan A. Fitch WL, et al. Among authors: lopez tapia f. Drug Metab Dispos. 2004 Dec;32(12):1482-90. doi: 10.1124/dmd.104.000471. Epub 2004 Sep 15. Drug Metab Dispos. 2004. PMID: 15371298