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Disposition of [14C]ruboxistaurin in humans.
Burkey JL, Campanale KM, Barbuch R, O'Bannon D, Rash J, Benson C, Small D. Burkey JL, et al. Among authors: o bannon d. Drug Metab Dispos. 2006 Nov;34(11):1909-17. doi: 10.1124/dmd.106.009894. Epub 2006 Aug 8. Drug Metab Dispos. 2006. PMID: 16896067 Clinical Trial.
Preclinical characterization of 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic acid metabolism: in vitro species comparison and in vivo disposition in rats.
Perkins EJ, Cramer JW, Farid NA, Gadberry MG, Jackson DA, Mattiuz EL, O'Bannon DD, Weiss HJ, Wheeler WJ, Wood PG, Cassidy KC. Perkins EJ, et al. Among authors: o bannon dd. Drug Metab Dispos. 2003 Nov;31(11):1382-90. doi: 10.1124/dmd.31.11.1382. Drug Metab Dispos. 2003. PMID: 14570771
In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.
Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P. Barbuch RJ, et al. Among authors: o bannon dd. Drug Metab Dispos. 2006 Feb;34(2):213-24. doi: 10.1124/dmd.105.007401. Epub 2005 Oct 28. Drug Metab Dispos. 2006. PMID: 16258078