Ryder TF[au] - Search Results

Year	Number of Results
2008	1
2009	3
2010	3
2011	1
2012	2
2013	2
2014	2
2018	1
2019	1
2022	1
2024	0

1

Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans.

Ryder TF, Bergman A, King-Ahmad A, Amin NB, Lall MS, Ballard TE, Kalgutkar AS. Ryder TF, et al. Xenobiotica. 2022 Mar;52(3):240-253. doi: 10.1080/00498254.2022.2062487. Epub 2022 Apr 13. Xenobiotica. 2022. PMID: 35382680

2

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Ryder TF, Calabrese MF, Walker GS, Cameron KO, Reyes AR, Borzilleri KA, Delmore J, Miller R, Kurumbail RG, Ward J, Kung DW, Brown JA, Edmonds DJ, Eng H, Wolford AC, Kalgutkar AS. Ryder TF, et al. J Med Chem. 2018 Aug 23;61(16):7273-7288. doi: 10.1021/acs.jmedchem.8b00807. Epub 2018 Aug 2. J Med Chem. 2018. PMID: 30036059

3

The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.

Dowty ME, Lin J, Ryder TF, Wang W, Walker GS, Vaz A, Chan GL, Krishnaswami S, Prakash C. Dowty ME, et al. Among authors: ryder tf. Drug Metab Dispos. 2014 Apr;42(4):759-73. doi: 10.1124/dmd.113.054940. Epub 2014 Jan 24. Drug Metab Dispos. 2014. PMID: 24464803

4

Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.

Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F. Adusumalli S, et al. Among authors: ryder tf. Drug Metab Dispos. 2019 Aug;47(8):874-882. doi: 10.1124/dmd.119.087015. Epub 2019 Jun 10. Drug Metab Dispos. 2019. PMID: 31182423 Free PMC article. Clinical Trial.

5

Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR.

Walker GS, Ryder TF, Sharma R, Smith EB, Freund A. Walker GS, et al. Among authors: ryder tf. Drug Metab Dispos. 2011 Mar;39(3):433-40. doi: 10.1124/dmd.110.036343. Epub 2010 Nov 22. Drug Metab Dispos. 2011. PMID: 21098098

6

Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.

Sharma R, Sun H, Piotrowski DW, Ryder TF, Doran SD, Dai H, Prakash C. Sharma R, et al. Among authors: ryder tf. Drug Metab Dispos. 2012 Nov;40(11):2143-61. doi: 10.1124/dmd.112.047316. Epub 2012 Aug 15. Drug Metab Dispos. 2012. PMID: 22896728

7

Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics.

Obach RS, Ryder TF. Obach RS, et al. Among authors: ryder tf. Drug Metab Dispos. 2010 Aug;38(8):1381-91. doi: 10.1124/dmd.110.034009. Epub 2010 May 17. Drug Metab Dispos. 2010. PMID: 20478852

8

Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies.

Walker GS, Bauman JN, Ryder TF, Smith EB, Spracklin DK, Obach RS. Walker GS, et al. Among authors: ryder tf. Drug Metab Dispos. 2014 Oct;42(10):1627-39. doi: 10.1124/dmd.114.059204. Epub 2014 Jul 22. Drug Metab Dispos. 2014. PMID: 25053618

9

Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.

Walsky RL, Bauman JN, Bourcier K, Giddens G, Lapham K, Negahban A, Ryder TF, Obach RS, Hyland R, Goosen TC. Walsky RL, et al. Among authors: ryder tf. Drug Metab Dispos. 2012 May;40(5):1051-65. doi: 10.1124/dmd.111.043117. Epub 2012 Feb 22. Drug Metab Dispos. 2012. PMID: 22357286

10

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor.

Kalgutkar AS, Ryder TF, Walker GS, Orr ST, Cabral S, Goosen TC, Lapham K, Eng H. Kalgutkar AS, et al. Among authors: ryder tf. Drug Metab Dispos. 2013 Jul;41(7):1375-88. doi: 10.1124/dmd.113.051839. Epub 2013 Apr 22. Drug Metab Dispos. 2013. PMID: 23610086

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