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Page 1
Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338.
Wong N, Petronijević F, Hong AY, Linghu X, Kelly SM, Hou H, Cravillion T, Lim NK, Robinson SJ, Han C, Molinaro C, Sowell CG, Gosselin F. Wong N, et al. Among authors: sowell cg. Org Lett. 2019 Nov 15;21(22):9099-9103. doi: 10.1021/acs.orglett.9b03481. Epub 2019 Oct 31. Org Lett. 2019. PMID: 31668077
Macrolactamization Approaches to Arylomycin Antibiotics Core.
Lim NK, Linghu X, Wong N, Zhang H, Sowell CG, Gosselin F. Lim NK, et al. Among authors: sowell cg. Org Lett. 2019 Jan 4;21(1):147-151. doi: 10.1021/acs.orglett.8b03603. Epub 2018 Dec 19. Org Lett. 2019. PMID: 30565949
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Gallion S, Hymowitz SG, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Maurer B, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Sowell CG, Wang X, Wong H, Xiong JM, Xu J, Zhao Z, Currie KS. Young WB, et al. Among authors: sowell cg. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7. doi: 10.1016/j.bmcl.2015.01.032. Epub 2015 Feb 7. Bioorg Med Chem Lett. 2015. PMID: 25701252
3-O-Desacyl monophosphoryl lipid A derivatives: synthesis and immunostimulant activities.
Johnson DA, Keegan DS, Sowell CG, Livesay MT, Johnson CL, Taubner LM, Harris A, Myers KR, Thompson JD, Gustafson GL, Rhodes MJ, Ulrich JT, Ward JR, Yorgensen YM, Cantrell JL, Brookshire VG. Johnson DA, et al. Among authors: sowell cg. J Med Chem. 1999 Nov 4;42(22):4640-9. doi: 10.1021/jm990222b. J Med Chem. 1999. PMID: 10579826
Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.
Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H. Liu L, et al. Among authors: sowell cg. Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8. Drug Metab Dispos. 2011. PMID: 21742900