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Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.
Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M. Taguchi K, et al. Among authors: ujihira h. Toxicol Appl Pharmacol. 2010 Nov 1;248(3):234-41. doi: 10.1016/j.taap.2010.08.006. Epub 2010 Aug 13. Toxicol Appl Pharmacol. 2010. PMID: 20709091
Pharmacokinetic study of adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute in an anticancer drug-induced thrombocytopenia rat model.
Taguchi K, Ujihira H, Watanabe H, Fujiyama A, Doi M, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T. Taguchi K, et al. Among authors: ujihira h. J Pharm Sci. 2013 Oct;102(10):3852-9. doi: 10.1002/jps.23692. Epub 2013 Aug 5. J Pharm Sci. 2013. PMID: 23918456
Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen γ-chain dodecapeptide as a synthetic platelet substitute.
Taguchi K, Ujihira H, Ogaki S, Watanabe H, Fujiyama A, Doi M, Okamura Y, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T. Taguchi K, et al. Among authors: ujihira h. Drug Metab Dispos. 2013 Aug;41(8):1584-91. doi: 10.1124/dmd.112.050005. Epub 2013 Jun 4. Drug Metab Dispos. 2013. PMID: 23735758