An increase in drug metabolic clearance results in a decrease in concentration of parent
drug but the effect on concentration of metabolite has been unclear. The effect of increases in …

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The effect of meals on valproic acid (VPA) absorption from an enteric coated (EC) formulation
was investigated. In study I, six adult normal volunteers received a single 500 mg dose of …

Sodium valproate (VPA) was administered for 1 week (1 g bid) to seven epileptic patients
receiving chronic carbamazepine (CBZ) therapy. Steady‐state CBZ levels determined before …

A specific procedure for the analysis of clobazam and N-desmethylclobazam in plasma is
described. Reversed-phase liquid chromatography was performed on a Radial-pak cartridge …

Patients on long term valproate treatment exhibit unusual fluctuations in steady-state plasma
levels of valproic acid. In order to delineate the underlying mechanisms of these fluctuations…

Blood concentrations of phenobarbital, following an intramuscular administration of a single
large dose of approximately 10 mg/kg, were studied in 39 infants. A rapid rise was obtained …

The kinetics of clobazam taken 3 h before, during, and 3 h after a standard hospital meal
were studied in six healthy volunteers. Peak plasma levels were significantly lower when the …

High-dose thiopental was administered in 8 children with uncontrollable seizures or hypoxic
encephalopathy (group A) and 7 full-term neonates with neonatal asphyxia (group B), All of …

Due to the spread of chloroquine-resistant strains of Plasmodium falciparum in French
speaking parts of Africa, we have found it necessary to prescribe mefloquine for antimalaria …