User profiles for A Guillouzo
Andre GuillouzoUniversité de Rennes 1 Verified email at univ-rennes1.fr Cited by 23875 |
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in …
…, C Lohmann, C Skonberg, A Guillouzo… - Drug metabolism …, 2007 - Taylor & Francis
This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …
Liver cell models in in vitro toxicology.
A Guillouzo - Environmental health perspectives, 1998 - ehp.niehs.nih.gov
In vitro liver preparations are increasingly used for the study of hepatotoxicity of chemicals.
In recent years their actual advantages and limitations have been better defined. The cell …
In recent years their actual advantages and limitations have been better defined. The cell …
General review on in vitro hepatocyte models and their applications
C Guguen-Guillouzo, A Guillouzo - Hepatocytes: methods and protocols, 2010 - Springer
In vitro hepatocyte models represent very useful systems in both fundamental research and
various application areas. Primary hepatocytes appear as the closest model for the liver in …
various application areas. Primary hepatocytes appear as the closest model for the liver in …
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
…, F Morel, C Guguen-Guillouzo, A Guillouzo - Drug metabolism and …, 2006 - ASPET
Most human hepatocyte cell lines lack a substantial set of liver-specific functions, especially
major cytochrome P450 (P450)-related enzyme activities, making them unrepresentative of …
major cytochrome P450 (P450)-related enzyme activities, making them unrepresentative of …
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
…, L Corcos, B Turlin, P Beaune, A Guillouzo - Molecular …, 1993 - ASPET
Cytokines are thought to cause the depression of cytochrome P-450 (CYP)-associated drug
metabolism in humans during inflammation and infection. We have examined the role of five …
metabolism in humans during inflammation and infection. We have examined the role of five …
Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type
C Guguen-Guillouzo, B Clément, G Baffet… - Experimental cell …, 1983 - Elsevier
When adult rat hepatocytes were co-cultured with another liver epithelial cell type in a medium
supplemented or not with fetal calf serum (FCS), it was found that 1. 1. They survived for …
supplemented or not with fetal calf serum (FCS), it was found that 1. 1. They survived for …
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells
…, J Uusitalo, C Guguen-Guillouzo, A Guillouzo - Drug Metabolism and …, 2010 - ASPET
HepaRG cells possess the unique property to differentiate in vitro and to express various
functions of mature hepatocytes, including the major cytochromes P450 (P450s). In the present …
functions of mature hepatocytes, including the major cytochromes P450 (P450s). In the present …
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
A Guillouzo, A Corlu, C Aninat, D Glaise, F Morel… - Chemico-biological …, 2007 - Elsevier
Although they have several important limitations primary human hepatocytes still represent
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …
The P-glycoprotein multidrug transporter
O Fardel, V Lecureur, A Guillouzo - General Pharmacology: The Vascular …, 1996 - Elsevier
1. P-glycoprotein (P-gp) is a transmembrane protein involved in ATP-dependent efflux of
various structurally unrelated anticancer drugs. Its overexpression in cancer cells decreases …
various structurally unrelated anticancer drugs. Its overexpression in cancer cells decreases …
Opposite regulation of human versus mouse apolipoprotein AI by fibrates in human apolipoprotein AI transgenic mice.
The regulation of liver apolipoprotein (apo) AI gene expression by fibrates was studied in
human apo AI transgenic mice containing a human genomic DNA fragment driving apo AI …
human apo AI transgenic mice containing a human genomic DNA fragment driving apo AI …