One of the factors determining the toxicity of chlorpyrifos (CPS), an organophosphorus (OP)
insecticide, is its biotransformation. CPS can be activated by cytochrome P450 (CYP) …

Despite the amount of hard work that has gone into elucidating a toxicological basis for Gulf
War Illness, we do not appear to have reached a mechanistic understanding. Investigation of …

Oxidative metabolism of the insect repellentN,N-diethyl-m-toluamide (DEET) by pooled
human liver microsomes (HLM), rat liver microsomes (RLM), and mouse liver microsomes (MLM) …

Two mouse immunoglobulin G1 monoclonal antibodies that bind to the trichothecene mycotoxin
T-2 were prepared. These antibodies, designated 12C12 and 15H6, had affinities for T-…

We recently published electron paramagnetic resonance (EPR) spin trapping results that
demonstrated the enzymatic reduction of sulfur mustard sulfonium ions to carbon-based free …

The biochemical sequelae to chloroethyl mustard exposure correspond very well to toxic
processes initiated by free radicals. Additionally, mustard solutions contain spontaneously …

The production of antibodies against the organophosphorus hapten soman has been
undertaken in vivo in rabbits and in vitro by employing monoclonal techniques. The polyclonal …

Transition state stabilization is considered one means by which enzymes reduce free
energy of activation. The transition state of phosphonic acid anhydrides acted on by OPA …

Mice were immunized with (p-aminophenyl) paraoxon conjugated to protein by diazotization.
The production and isolation of permanent hybridoma cell lines from the splenic …

The organophosphorus compound soman (methylphosphonofluoridic acid 1, 2, 2-trimethylpropyl
ester) is a potent cholinesterase inhibitor [1, 2] and a chemical warfare agent. The rapid …