Circadian rhythms are daily cycles of physiology and behaviour that are driven by an
endogenous oscillator with a period of approximately (circa-) one day (diem). Exemplified in …

Circadian rhythms permeate mammalian biology. They are manifested in the temporal
organisation of behavioural, physiological, cellular and neuronal processes. Whereas it has been …

Circadian rhythms coordinate our physiology at a fundamental level. Over the last 20 years,
we have witnessed a paradigm shift in our perception of what the clocks driving such …

Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms
have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage …

Background: Genes encoding the circadian pacemaker in the hypothalamic suprachiasmatic
nuclei (SCN) of mammals have recently been identified, but the molecular basis of …

Circadian (∼24 hour) clocks are fundamentally important for coordinated physiology in
organisms as diverse as cyanobacteria and humans. All current models of the molecular …

Circadian rhythms are essential to health. Their disruption is associated with metabolic diseases
in experimental animals and man [1–3]. Local metabolic rhythms represent an output of …

Circadian rhythms are ubiquitous in eukaryotes, and coordinate numerous aspects of
behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and …

… Furthermore, we show that depolarization and treatment with a second SCN neuropeptide,
GRP, acutely activates and synchronizes molecular clocks in the absence of VIPergic signals. …

… Dr Reddy acknowledges funding from the Wellcome Trust (grant 100333/Z/12/Z). We
acknowledge Roche Applied Science for the generous loan of the Light Cycler 480 instrument on …