Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
V Subrahmanyam, AB Renwick, DG Walters… - Drug Metabolism and …, 2001 - ASPET
The metabolism of cis-tramadol has been studied in human liver microsomes and in cDNA-expressed
human cytochrome P-450 (CYP) isoforms. Human liver microsomes catalyzed the …
human cytochrome P-450 (CYP) isoforms. Human liver microsomes catalyzed the …
Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
AB Renwick, PS Watts, RJ Edwards, PT Barton… - Drug Metabolism and …, 2000 - ASPET
The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied
in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 …
in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 …
Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase
BG Lake, SE Ball, J Kao, AB Renwick, RJ Price… - Xenobiotica, 2002 - Taylor & Francis
1. The metabolism of Zaleplon (CL-284,846; ZAL) has been studied in precision-cut human
liver slices and liver cytosol preparations. 2. Human liver slices metabolized ZAL to a number …
liver slices and liver cytosol preparations. 2. Human liver slices metabolized ZAL to a number …
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices
RJ Edwards, RJ Price, PS Watts, AB Renwick… - Drug metabolism and …, 2003 - ASPET
Precision-cut human liver slices obtained from 11 donors were cultured for 72 h in a defined
medium (serum free Williams' medium E) supplemented with 0.1 μM insulin and 0.1 μM …
medium (serum free Williams' medium E) supplemented with 0.1 μM insulin and 0.1 μM …
Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices
AB Renwick, SE Ball, JM Tredger, RJ Price… - Xenobiotica, 2002 - Taylor & Francis
1. The effect of cimetidine on the metabolism of zaleplon (ZAL) in human liver subcellular
fractions and precision-cut liver slices was investigated. 2. ZAL was metabolized to a number of …
fractions and precision-cut liver slices was investigated. 2. ZAL was metabolized to a number of …
Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems
…, P Watts, BG Lake, RJ Price, AB Renwick… - Drug metabolism and …, 2003 - ASPET
Selegiline was used as a model compound in a project aimed at comparing, evaluating,
and integrating different in vitro approaches for the prediction of cytochrome P450 (P450)-…
and integrating different in vitro approaches for the prediction of cytochrome P450 (P450)-…
Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices
C Meredith, MP Scott, AB Renwick, RJ Price… - Xenobiotica, 2003 - Taylor & Francis
1. Real-time quantitative reverse transcription-polymerase chain reaction methodology (TaqMan®)
was used to examine the induction of some selected rat hepatic cyto-chrome P450 (…
was used to examine the induction of some selected rat hepatic cyto-chrome P450 (…
Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems
…, AR Boobis, P Watts, BG Lake, RJ Price, AB Renwick… - xenobiotica, 2001 - Taylor & Francis
1. The ability of various in vitro systems for CYP enzymes (computer modelling, human liver
microsomes, precision-cut liver slices, hepatocytes in culture, recombinant enzymes) to …
microsomes, precision-cut liver slices, hepatocytes in culture, recombinant enzymes) to …
Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms
AB Renwick, D Surry, RJ Price, BG Lake, DC Evans - Xenobiotica, 2000 - Taylor & Francis
1. The metabolism of 7-benzyloxy-4-trifluoromethylcoumarin (BFC) to 7-hydroxy-4-trifluoromethylcoumarin
(HFC) was studied in human liver microsomal preparations and in cDNA-…
(HFC) was studied in human liver microsomal preparations and in cDNA-…
Metabolism of 2, 5-bis (trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4
AB Renwick, DFV Lewis, S Fulford, D Surry… - Xenobiotica, 2001 - Taylor & Francis
Isoforms of the cytochrome P450 (CYP) superfamily are known to play a major role in the
oxidative metabolism of both xenobiotics and certain endogenous compounds (Parkinson 1996…
oxidative metabolism of both xenobiotics and certain endogenous compounds (Parkinson 1996…