User profiles for A. C. Eddy

Adrian Eddy

Nationwide Children's Hospital
Verified email at nationwidechildrens.org
Cited by 176

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

…, KL Kunze, RF Lawrence, AC Eddy… - Chemical research in …, 1992 - ACS Publications
Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in
human liver microsomes which appears to be responsible for the termination of warfarin’s …

Growth differentiation factor-15 and its role in diabetes and cardiovascular disease

AC Eddy, AJ Trask - Cytokine & growth factor reviews, 2021 - Elsevier
Growth differentiation factor-15 (GDF-15) is cytokine involved in the regulation of multiple
systems. Because it has regularly been shown to be increased in cardiovascular disease (CVD…

[HTML][HTML] Pro-angiogenic therapeutics for preeclampsia

AC Eddy, GL Bidwell III, EM George - Biology of sex differences, 2018 - Springer
Preeclampsia is a pregnancy-induced hypertensive disorder resulting from abnormal
placentation, which causes factors such as sFlt-1 to be released into the maternal circulation. …

The mechanism of the interaction between amiodarone and warfarin in humans

…, K Kunze, M Gibaldi, AC Eddy… - Clinical …, 1992 - Wiley Online Library
… Of the recovered radioactivity from urine, 86% (62.57% of the administered dose) could be
accounted for in known metabolites, whereas of the recovered radioactivity from the stool, 89…

Empyema thoracis in patients undergoing emergent closed tube thoracostomy for thoracic trauma

AC Eddy, GK Luna, M Copass - The American journal of surgery, 1989 - Elsevier
The vast majority of thoracic trauma victims require only observation or tube thoracostomy
for definitive treatment of their thoracic injury. Although tube thoracostomy is generally …

Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice

AD Kenney, A Zani, J Kawahara, AC Eddy, XL Wang… - EMBO …, 2023 - embopress.org
Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein that alters cell
membranes to block fusion of viruses. Conflicting reports identified opposing effects of IFITM3 …

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

…, A Webb, J Kawahara, AC Eddy… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health
concern, and new treatment strategies are needed. Targeting inflammatory innate immunity …

The epidemiology of traumatic rupture of the thoracic aorta in children: a 13-year review

AC EDDY, VW RUSCH, CL FLIGNER… - Journal of Trauma …, 1990 - journals.lww.com
… It is particularly important that Doctor Eddy has pointed out the value of seatbelts and car …
I commend Doctor Eddy for stating this point and for also supporting it with data. Although this …

[HTML][HTML] Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

…, KK Lai, AD Kenney, A Zani, AC Eddy… - The Journal of …, 2022 - Am Soc Clin Investig
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised
individuals is associated with prolonged virus shedding and evolution of viral variants…

[HTML][HTML] Modified conduit preparation creates a pseudosinus in an aortic valve–sparing procedure for aneurysm of the ascending aorta

RP Cochran, KS Kunzelman, AC Eddy, BO Hofer… - The Journal of thoracic …, 1995 - Elsevier
… The sinuses, in concert with the sinotubular junction, create eddy currents within the
supravalvular region that initiate valve closure and promote coronary artery blood flow. This eddy