Amphipathic asymmetric dendrimers have been investigated for use in delivery of genes
into cells, with the objective of optimising transfection efficiency and maintaining cell viability. …

The genes which encode glycosomal glyceraldehyde‐phosphate dehydrogenase (gGAPDH)
of Trypanosoma cruzi are arranged as a tandemly repeated pair on a single chromosome …

The STAT3 transcription factor plays a central role in a wide range of cancer types where it
is over-expressed. Previously, phosphorylation of this protein was thought to be a …

Purification of the active proteinase from mature HIV-1 particles has been attempted without
success (see for example Ref. 7). Such efforts have been limited to only a few groups …

STAT3 (Signal Transducer and Activator of Transcription factor 3) is constitutively active in a
wide range of human tumours. Stattic is one of the first non-peptidic small molecules …

Incorporation of 4.5 nmol fluorescein isothiocyanate/mg rabbit sarcoplasmic reticulum, or of
7.4 nmol/mg purified ATPase, was sufficient to inhibit the activity completely. These results …

Dendrimers are nonviral vectors that have attracted interest on account of a number of
features. They are structurally versatile because their size, shape, and surface charge can be …

The interaction of DNA with partial dendrimers (dendritic polylysine containing seven
lysines and eight terminal amino groups with or without a lipidic core) was studied. Compact …

We investigated the potential of a new family of lipidic peptide dendrimers in protein transduction
into cultured cells. Dendrimer–protein interaction was determined by gel retardation …

A small library of pyrrolidinesulphonylaryl molecules has been synthesized via an efficient 4-step
route, and members evaluated for their ability to inhibit IL-6 signalling. One molecule (…