Drug‐induced liver injury (DILI) is the most frequent reason cited for the withdrawal of
approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. …

Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug metabolism but
the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute. CYP3A5 is the best …

Genome-wide association (GWA) studies for pharmacogenomics-related traits are
increasingly being performed to identify loci that affect either drug response or susceptibility to …

Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1 , 2 , 3 , 4 – 5 . Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been …

… Ann K Daly, PhD Ann K Daly … Christopher Day and Ann Daly jointly supervised the study
and revised the paper. Patrick Kesteven contributed to the study design and data analysis. …

Drug-induced liver injury (DILI) is an important cause of serious liver disease. The antimicrobial
agent flucloxacillin is a common cause of DILI, but the genetic basis for susceptibility …

Current dosing algorithms do not account for genetic and environmental factors for warfarin
dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 …

Background The level of anticoagulation in response to a fixed-dose regimen of warfarin is
difficult to predict during the initiation of therapy. We prospectively compared the effect of …

Inherited factors play a major role in the predisposition to nonalcoholic fatty liver disease (NAFLD),
and the rs738409 C→G polymorphism of PNPLA3/adiponutrin, encoding for the …

Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly
associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis …