User profiles for A. K. Daly
Ann DalyProfessor of Pharmacogenetics, Newcastle University Verified email at ncl.ac.uk Cited by 42605 |
Case definition and phenotype standardization in drug‐induced liver injury
Drug‐induced liver injury (DILI) is the most frequent reason cited for the withdrawal of
approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. …
approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. …
Significance of the minor cytochrome P450 3A isoforms
AK Daly - Clinical pharmacokinetics, 2006 - Springer
Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug metabolism but
the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute. CYP3A5 is the best …
the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute. CYP3A5 is the best …
Genome-wide association studies in pharmacogenomics
AK Daly - Nature Reviews Genetics, 2010 - nature.com
Genome-wide association (GWA) studies for pharmacogenomics-related traits are
increasingly being performed to identify loci that affect either drug response or susceptibility to …
increasingly being performed to identify loci that affect either drug response or susceptibility to …
[HTML][HTML] NASH limits anti-tumour surveillance in immunotherapy-treated HCC
…, A D'alessio, N Personeni, L Rimassa, AK Daly… - Nature, 2021 - nature.com
Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1 , 2 , 3 , 4 – 5 . Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been …
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been …
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
… Ann K Daly, PhD Ann K Daly … Christopher Day and Ann Daly jointly supervised the study
and revised the paper. Patrick Kesteven contributed to the study design and data analysis. …
and revised the paper. Patrick Kesteven contributed to the study design and data analysis. …
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Drug-induced liver injury (DILI) is an important cause of serious liver disease. The antimicrobial
agent flucloxacillin is a common cause of DILI, but the genetic basis for susceptibility …
agent flucloxacillin is a common cause of DILI, but the genetic basis for susceptibility …
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen
…, L Monkhouse, BP King, P Wood, P Kesteven, AK Daly… - Blood, 2005 - ashpublications.org
Current dosing algorithms do not account for genetic and environmental factors for warfarin
dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 …
dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 …
[HTML][HTML] A randomized trial of genotype-guided dosing of warfarin
…, PR Williamson, AK Daly… - … England Journal of …, 2013 - Mass Medical Soc
Background The level of anticoagulation in response to a fixed-dose regimen of warfarin is
difficult to predict during the initiation of therapy. We prospectively compared the effect of …
difficult to predict during the initiation of therapy. We prospectively compared the effect of …
[PDF][PDF] Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
Inherited factors play a major role in the predisposition to nonalcoholic fatty liver disease (NAFLD),
and the rs738409 C→G polymorphism of PNPLA3/adiponutrin, encoding for the …
and the rs738409 C→G polymorphism of PNPLA3/adiponutrin, encoding for the …
[HTML][HTML] TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly
associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis …
associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis …