… The effects of androgens are modulated at cellular level by the steroid-converting enzymes
within the particular target tissue (Figure 1). In reproductive target tissues, testosterone can …

… Dr AT Kicman E-mail: andrew.kicman@kcl.ac.uk This article has been prepared at the …
the suspicion of their extensive use by competitors at international level. For example, it was …

… in rodents at very high doses and that significant serotonergic toxicity was only found at doses
… at large but this could lead to the taking of much larger doses, with unanticipated effects. …

… In this study, a single relatively small dose caused an acute rise in AVP concentration at a
time of day when it would not be expected to change. The rise in AVP was accompanied by a …

… Following extraction with hexane under basic conditions, additional peaks were detected
two with the highest mass ion at m/z 430 and one at m/z 428. More thorough hydrolysis, using …

… The corresponding MDA enantiomer concentrations were maintained at one-… at 80 C for 20
min. After derivatization, the organic phase was evaporated to dryness under nitrogen at 30 C…

… Urine samples were collected over 2 h periods from 0 h, 2 h, 4 h, 6 h, 8 h and then spot
collections at exactly 12 h, 24 h, 30 h and at day 2 (48 h), 3 (72 h), 4 (96 h), 5 (120 h), 6 (144 h), 7 …

… Although all target analytes were readily detected at 500 ng/ml, a cut-off of 1000 ng/ml was
… was set at 0.400 ml/min with an injection volume of 15 µl. The auto-sampler was kept at 20 …

… the solvent was evaporated to dryness under nitrogen at 60 … ) were taken and evaporated
to dryness under nitrogen at 60 … derivatized to form methyloximes by heating at 60 ◦ C for 1 h …

… During the administration study, three blood (serum and whole blood) collection points
were missed (volunteer 1 at 15 min and volunteer 3 at 15 min and 6 h). The mean GHB …