[HTML][HTML] Identification of pyrazolopyridazinones as PDEδ inhibitors

…, K Heinelt, C Schultz-Fademrecht, A Al Saabi… - Nature …, 2016 - nature.com
… You are using a browser version with limited support for CSS. To obtain the best experience,
we recommend you use a more up to date browser (or turn off compatibility mode in Internet …

Involvement of UDP-glucuronosyltransferases UGT1A9 and UGT2B7 in ethanol glucuronidation, and interactions with common drugs of abuse

A Al Saabi, D Allorge, FL Sauvage, G Tournel… - Drug Metabolism and …, 2013 - ASPET
… BSA is known to affect the kinetics of UGT1A9 and 2B7 (Rowland et al., 2007, 2008).
Consistent with previous observations, we observed a decrease in enzyme K m and a consecutive …

Development of pyridazinone chemotypes targeting the PDEδ prenyl binding site

…, C Schultz‐Fademrecht, A Al Saabi… - Chemistry–A …, 2017 - Wiley Online Library
… of a fluorescence polarization assay based on a known PDEδ ligand. Our results show that
introduction of a methyl substituent on the phenyl ring of the amide functionality leads to a two…

[HTML][HTML] Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene

M Soichot, B Hennart, A Al Saabi, A Leloire, P Froguel… - PLoS …, 2011 - journals.plos.org
… Furthermore, females with a *V2/*V2 genotype displayed a significant and a trend toward
lower serum Trp concentration compared to females with a *V1/*V2 and *V1/*V1 genotype, …

Removal of Bacillus spores from stainless steel pipes by flow foam: Effect of the foam quality and velocity

A Al Saabi, H Dallagi, F Aloui, C Faille… - Journal of Food …, 2021 - Elsevier
… The SDS solution is pumped into the feeding tank (50 L) located at a height of 3 m using
a positive displacement pump (VARMECA 21TL055, Leroy-Somer). This set-up creates a

Influence of chronic ethanol consumption on the neurological severity in patients with acute cerebral ischemia

A Ducroquet, D Leys, AA Saabi, F Richard… - Stroke, 2013 - Am Heart Assoc
… We defined heavy drinkers by a weekly consumption of ethanol of ≥300 g and severe …
We tested the hypothesis that a chronic excessive consumption of ethanol is associated with a

CFD characterization of a wet foam flow rheological behavior

H Dallagi, R Gheith, A Al Saabi… - Fluids …, 2018 - asmedigitalcollection.asme.org
a robust model to describe the foam fluid inside horizontal channels by the reverse approach
of a … : the first one for a wet foam flow with a void fraction of 70% and a foam flow velocity of …

CFD simulations of the rheological behavior of aqueous foam flow through a half-sudden expansion

H Dallagi, A Al Saabi, C Faille… - Fluids …, 2019 - asmedigitalcollection.asme.org
… flow structure of foams through a plane sudden expansion by using a geometry that has … a
horizontal channel (Figure 1) of length 3.87m, undergoing a sudden widening at x = 0m with a

[PDF][PDF] Investigating the Effect of the Fretting Corrosion Phenomenon on the use of Polymeric and Metallic Material, CoCrMo (1% Ti), PEKK and PEKK (30% CF) …

A Al Saabi - 2014 - researchgate.net
A typical assessment of this experimental fact is the slow … Raman spectroscopy was a
justifiable method and showed a … The search of a better couple is a need to enhance the life …

Intérêt de l'Ethylglucuronide comme marqueur d'alcoolisation: développement de méthodes de dosage et étude des sources de variabilité de sa production

A Al Saabi - 2013 - theses.hal.science
… Cela a été un grand plaisir de travailler et de partager ce projet de recherche avec toi. …
profile of a subject and a specific and sensitive, thus reliable, diagnosis. As a direct metabolite of …