It has long been recognized that cancer onset and progression represent a type of reversion
to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the …

… GSTP1 * C has valine at position 105 and also valine at position 114 caused by a C→T …
Anneke Blackburn developed the PCR technique. George Mellick isolated the DNA. David Le …

The glycolytic phenotype is a widespread phenomenon in solid cancer forms, including breast
cancer. Dichloroacetate (DCA) has recently been proposed as a novel and relatively non-…

The thermodynamically most stable polymorph under ambient conditions is almost without
exception the most desirable crystalline form for development by a pharmaceutical company. …

The human p53 tumor suppressor gene TP53 is mutated at a high frequency in sporadic
breast cancer, and Li-Fraumeni syndrome patients who carry germline mutations in one TP53 …

Background Cancer cells have a different metabolic profile compared to normal cells. The
Warburg effect (increased aerobic glycolysis) and glutaminolysis (increased mitochondrial …

There are two functional Omega class glutathione transferase (GST) genes in humans.
GSTO1 is polymorphic with several coding region alleles, including an A140D substitution, a …

… Although this report dispelled the rumor that most gifted students excel academically on
their own, the myth still persists that healthy emotional development among the gifted is …

… The almost buried active site is reminiscent of the human theta class structure but in the
latter case the active site is covered by a C-terminal helical extension ( 33). The MAAI residues …

Epithelial cancers comprise 80-90% of human cancers. During the process of cancer progression,
cells lose their epithelial characteristics and acquire stem-like mesenchymal features …