Using the mouse as a model organism in pharmaceutical research presents unique advantages
as its physiology in many ways resembles the human physiology, it also has a relatively …

CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the
metabolism of endogenous substrates, whereas the CYP2C18 enzyme is not expressed in …

ADAMTS1, a secreted multifunctional metalloproteinase with disintegrin and thrombospondin
motifs, is an early response gene of parathyroid hormone (PTH) in osteoblasts. Mice …

Synthetic glucocorticoids (GC) are essential for the treatment of a broad range of inflammatory
diseases. However, their use is limited by target related adverse effects on, eg, glucose …

Background Glucocorticoids are highly effective and widely used anti-inflammatory drugs,
but their use is limited by serious side-effects, including glucocorticoid-induced …

Nowadays, distribution utilities face new technical-economical requirements, aiming at improving
the profitability of the electricity distribution systems. Such context requires both, a high …

This paper concentrates in the harmonics disturbances survey in Edenor distribution utility.
The disturbances survey (harmonics and flicker) is mandatory to the utility due to the control (…

Intelligent design, a term coined by early theologians as a proof of God, asserted that something
with a complex design must have had a designer. Subsequently, early twentieth century …

Background BET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain
containing proteins, which form a class of transcriptional co-regulators. BET proteins …

This paper deals with the experience of a private owner distribution utility in Argentina, face
to the Governmental Regulatory Agency that controls the quality of service to the customers. …