Destruction of peripheral C‐fibers does not alter subsequent vagus nerve stimulation‐induced seizure suppression in rats

SE Krahl, SS Senanayake, A Handforth - Epilepsia, 2001 - Wiley Online Library
Purpose: Early animal studies of the therapeutic mechanisms of vagus nerve stimulation (VNS)
suggested that seizure suppression requires maximal activation of small, unmyelinated …

Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial

A Handforth, CM DeGiorgio, SC Schachter… - Neurology, 1998 - AAN Enterprises
Objective: The purpose of this multicenter, add-on, double-blind, randomized, active-control
study was to compare the efficacy and safety of presumably therapeutic (high) vagus nerve …

[HTML][HTML] A comparison of four treatments for generalized convulsive status epilepticus

…, C Colling, AJ Rowan, A Handforth… - … England Journal of …, 1998 - Mass Medical Soc
Background and Methods Although generalized convulsive status epilepticus is a life-threatening
emergency, the best initial drug treatment is uncertain. We conducted a five-year …

Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy

…, MR Sperling, A Sharan, E Sandok, A Handforth… - Neurology, 2015 - AAN Enterprises
Objective: To report long-term efficacy and safety results of the SANTE trial investigating deep
brain stimulation of the anterior nucleus of the thalamus (ANT) for treatment of localization-…

Prospective long‐term study of vagus nerve stimulation for the treatment of refractory seizures

CM DeGiorgio, SC Schachter, A Handforth… - …, 2000 - Wiley Online Library
Purpose: To determine the long‐term efficacy of vagus nerve stimulation (VNS) for refractory
seizures. VNS is a new treatment for refractory epilepsy. Two short‐term double‐blind trials …

Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy

…, M Sperling, E Sandok, J Neal, A Handforth… - …, 2010 - Wiley Online Library
Purpose: We report a multicenter, double‐blind, randomized trial of bilateral stimulation of
the anterior nuclei of the thalamus for localization‐related epilepsy. Methods: Participants …

Mice lacking the β3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome

TM DeLorey, A Handforth… - Journal of …, 1998 - Soc Neuroscience
Angelman syndrome (AS) is a severe neurodevelopmental disorder resulting from a deletion/mutation
in maternal chromosome 15q11–13. The genes in 15q11–13 contributing to the …

Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior

…, JJ Quinlan, A Handforth… - Proceedings of the …, 1997 - National Acad Sciences
γ-Aminobutyric acid type A receptors (GABA A -Rs) mediate the bulk of rapid inhibitory synaptic
transmission in the central nervous system. The β3 subunit is an essential component of …

Current opinions and consensus for studying tremor in animal models

SH Kuo, ED Louis, PL Faust, A Handforth, S Chang… - The Cerebellum, 2019 - Springer
Tremor is the most common movement disorder; however, we are just beginning to understand
the brain circuitry that generates tremor. Various neuroimaging, neuropathological, and …

Deep brain stimulation of the subthalamic nucleus as adjunct treatment for refractory epilepsy

A Handforth, AAF DeSalles, SE Krahl - Epilepsia, 2006 - Wiley Online Library
Purpose: We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS)
for refractory partial‐onset epilepsy in two cases. Methods: This was an open treatment …