Ticlopidine, clopidogrel, and prasugrel are thienopyridine prodrugs that inhibit adenosine‐5′‐diphosphate
(ADP)‐mediated platelet aggregation in vivo. These compounds are …

Throughout this Symposium the contributors are concerned with the “bringing together” of
numerous contributions dealing with back and leg pain over the past 75 years. These …

The aim of the current study is to identify the human cytochrome P450 (P450) isoforms
involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically …

Seventy cases of surgically documented herniated lumbar disc in children and adolescents
were analyzed. Twenty-six of the 70 cases were followed at least five years postoperatively. …

Study Design. A retrospective follow-up study was conducted in patients who underwent
decompressive laminectomy for degenerative lumbar spinal stenosis. Objectives. To describe …

Background and methods: Prasugrel is a novel orally active thienopyridine prodrug with
potent and long‐lasting antiplatelet effects. Platelet inhibition reflects inhibition of P2Y 12 …

Let F" be a totally real algebraic number field of finite degree, and B a quaternion algebra
over F'such that kk is isomorphic to M,(R) X HX---XH, where H denotes the Hamilton …

Background: The relationship between radiologic instability and its symptoms is controversial.
Previous authors consider flexion–extension radiographs to be of little value in evaluating …

The biotransformation of prasugrel to R-138727 (2-[1-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic
acid) involves rapid deesterification to R-95913 (…

A quantitative method for the determination of clopidogrel active metabolite (AM) in human
plasma was developed and validated using liquid chromatography–tandem mass …