This study was undertaken to examine the influence of changes in dietary carbohydrate and
protein content on the oxidation of antipyrine and theophylline in man. When the diets of 6 …

The CO-difference spectrum of microsomes from rats treated with the polychlorinated biphenyls
mixture, Aroclor 1254, has an absorption maximum at 448 nm. With ethylisocyananide …

… Porra and Jones [15], as described by Eiseman and Alvares [16]. Benzo[a]pyrene hydroxylase
activity … phine N-demethylase activity was determined as described earlier by Alvares and …

… Kappas, A., Anderson, KE, Conney, AH, and Alvares, AP: Influence of dietary protein and
carbohydrate on antipyrine and theophylline metabolism in man, CUN. PHARMACOL. THER. …

Drug‐metabolizing capacities were determined in 10 normal adults and 10 children in the age
range from 1 to 8 years. Among the latter, 2 were normal and 8 had biochemical evidence …

There were marked individual differences in the plasma levels of phenacetin after oral
administration of a 900‐mg dose to 9 normal volunteers eating their customary home diet. …

This study was undertaken to examine the influence of nutritional factors on the activity of
the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three …

The rat liver mixed function oxidase system which is responsible for the metabolism of
endogenous and exogenous compounds has been shown to be affected by lead and methyl …

Acute administration of lead to rats caused significant decreases in cytochrome P‐450,
ethylmorphine N‐demethylase, and aniline hydroxylase activities and prolonged hexobarbital‐…

Studies in animals have shown that many environmental pollutants induce the synthesis or
inhibit the activity of microsomal mixed-function oxygenases that metabolize drugs, …