User profiles for Afroz S. Mohammad
Afroz S MohammadSenior Clinical Pharmacologist, Abbvie Verified email at abbvie.com Cited by 1096 |
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases
In women, breast cancer is the most common cancer diagnosis and second most common
cause of cancer death. More than half of breast cancer patients will develop metastases to the …
cause of cancer death. More than half of breast cancer patients will develop metastases to the …
Molecular determinants of blood–brain barrier permeation
WJ Geldenhuys, AS Mohammad, CE Adkins… - Therapeutic …, 2015 - Future Science
The blood–brain barrier (BBB) is a microvascular unit which selectively regulates the permeability
of drugs to the brain. With the rise in CNS drug targets and diseases, there is a need to …
of drugs to the brain. With the rise in CNS drug targets and diseases, there is a need to …
Targeting the blood-brain barrier to prevent sepsis-associated cognitive impairment
…, AL Brichacek, AS Mohammad… - Journal of central …, 2019 - journals.sagepub.com
Sepsis is a systemic inflammatory disease resulting from an infection. This disorder affects
750 000 people annually in the United States and has a 62% rehospitalization rate. Septic …
750 000 people annually in the United States and has a 62% rehospitalization rate. Septic …
Liposomal irinotecan accumulates in metastatic lesions, crosses the blood-tumor barrier (BTB), and prolongs survival in an experimental model of brain metastases of …
AS Mohammad, JI Griffith, CE Adkins, N Shah… - Pharmaceutical …, 2018 - Springer
Purpose The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central
nervous system. However, given that the BTB has increased passive permeability we …
nervous system. However, given that the BTB has increased passive permeability we …
Quantitative fluorescence microscopy measures vascular pore size in primary and metastatic brain tumors
RK Mittapalli, CE Adkins, KA Bohn, AS Mohammad… - Cancer research, 2017 - AACR
Tumors residing in the central nervous system (CNS) compromise the blood–brain barrier (BBB)
via increased vascular permeability, with the magnitude of changes dependent on the …
via increased vascular permeability, with the magnitude of changes dependent on the …
[HTML][HTML] P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model
…, VK Manda, MI Nounou, AS Mohammad… - Frontiers in …, 2013 - frontiersin.org
The blood–brain barrier (BBB) is a specialized vascular interface that restricts the entry of
many compounds into brain. This is accomplished through the sealing of vascular endothelial …
many compounds into brain. This is accomplished through the sealing of vascular endothelial …
Brain distribution of a panel of epidermal growth factor receptor inhibitors using cassette dosing in wild-type and Abcb1/Abcg2-deficient mice
M Kim, JK Laramy, AS Mohammad, S Talele… - Drug Metabolism and …, 2019 - ASPET
Tyrosine kinase inhibitors that target the epidermal growth factor receptor (EGFR) have had
success in treating EGFR-positive tumors, including non–small-cell lung cancer (NSCLC). …
success in treating EGFR-positive tumors, including non–small-cell lung cancer (NSCLC). …
Characterization of passive permeability at the blood–tumor barrier in five preclinical models of brain metastases of breast cancer
CE Adkins, AS Mohammad, TB Terrell-Hall… - Clinical & experimental …, 2016 - Springer
The blood–brain barrier (BBB) is compromised in brain metastases, allowing for enhanced
drug permeation into brain. The extent and heterogeneity of BBB permeability in metastatic …
drug permeation into brain. The extent and heterogeneity of BBB permeability in metastatic …
[HTML][HTML] Enhancing brain retention of a KIF11 inhibitor significantly improves its efficacy in a mouse model of glioblastoma
Glioblastoma, the most lethal primary brain cancer, is extremely proliferative and invasive.
Tumor cells at tumor/brain-interface often exist behind a functionally intact blood-brain barrier (…
Tumor cells at tumor/brain-interface often exist behind a functionally intact blood-brain barrier (…
[HTML][HTML] NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer
Background Brain metastases are an increasing problem in women with invasive breast
cancer. Strategies designed to treat brain metastases of breast cancer, particularly …
cancer. Strategies designed to treat brain metastases of breast cancer, particularly …