GPR40, one of the G protein-coupled receptors predominantly expressed in pancreatic β-cells,
mediates enhancement of glucose-stimulated insulin secretion by free fatty acids. A …

Replication stress (RS) is a cancer hallmark; chemotherapeutic drugs targeting RS are
widely used as treatments for various cancers. To develop next-generation RS-inducing …

To optimize the strategies for population-based pharmacogenetic studies, we extensively
analyzed single-nucleotide polymorphisms (SNPs) and haplotypes in 199 drug-related genes, …

Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA
replication. We developed a highly specific CDC7 inhibitor, TAK-931, as a clinical cancer …

6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
(TAK-441) is a potent, …

The absorption, distribution, metabolism, and excretion of fasiglifam were investigated in rats,
dogs, and humans. The absolute oral bioavailability of fasiglifam was high in all species (>…

Following oral administration of [ 14 C]TAK-438, the radioactivity was rapidly absorbed in
rats and dogs. The apparent absorption of the radioactivity was high in both species. 2. After …

Background Vonoprazan fumarate (TAK-438) is a novel potassium-competitive acid blocker
that appears to exert a longer/more potent antisecretory effect than lansoprazole due to high …

TAK-448 is a kisspeptin analog with improved in vivo potency. In our previous studies in the
rat JDCaP prostate cancer model, TAK-448 showed more rapid and profound reductions in …

Azilsartan medoxomil potassium salt (TAK-491) is an orally administered angiotensin II type
1 receptor blocker for the treatment of hypertension and is an ester-based prodrug that is …