SPRYCEL (dasatinib, BMS-354825; Bristol-Myers Squibb, Princeton, NJ), a multiple kinase
inhibitor, is currently approved to treat chronic myelogenous leukemia and Philadelphia …

For cancer cells to survive and proliferate, they must escape normal immune destruction. One
mechanism by which this is accomplished is through immune suppression effected by up-…

Bruton’s tyrosine kinase (BTK), a non-receptor tyrosine kinase, is a member of the Tec family
of kinases and is essential for B cell receptor (BCR) mediated signaling. BTK also plays a …

A two-step degradation–reconstruction approach to the carbon-14 radiolabeling of alkyl
carboxylic acids is presented. Simple activation via redox-active ester formation was followed by …

An LC-MS/MS assay was developed and fully validated for the simultaneous quantitation of
two coadministered human monoclonal antibodies (mAbs), mAb-A and mAb-B of IgG4 …

Despite extensive work on homolytic versus heterolytic peroxide bondcleavage by iron
porphyrins, the nature of the corresponding reactions catalyzed by myoglobin (Mb) and …

Immunogenicity testing for antidrug antibodies (ADA) faces challenges when high levels of
the drug are present in clinical patient samples. In addition, most functional cell-based assays …

Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody–drug
conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-…

Chemoselective methionine bioconjugation with alkyne-bearing oxaziridine and alkyne-bearing
iodonium salts was investigated as a new platform for site-selective radiolabeling of …

Qualitative and quantitative determinations of hydroperoxides are of central importance in
many areas of biochemical research, but analysis of intact hydroperoxides by capillary gas …