Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

…, RG O'Brien, LA Perkins, RG Quisling, AL Shroads… - …, 2006 - publications.aap.org
OBJECTIVE. Open-label studies indicate that oral dichloroacetate (DCA) may be effective in
treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the …

Long-term safety of dichloroacetate in congenital lactic acidosis

M Abdelmalak, A Lew, R Ramezani, AL Shroads… - Molecular genetics and …, 2013 - Elsevier
We followed 8 patients (4 males) with biochemically and/or molecular genetically proven
deficiencies of the E1α subunit of the pyruvate dehydrogenase complex (PDC; 3 patients) or …

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity

AL Shroads, X Guo, V Dixit, HP Liu, MO James… - … of Pharmacology and …, 2008 - ASPET
Dichloroacetate (DCA) is an investigational drug for certain metabolic diseases. It is
biotransformed principally by the ζ-1 family isoform of glutathione transferase (GSTz1), also known …

Inhibition of glutathione S-transferase ζ and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity

…, GN Henderson, J Cheung, AL Shroads… - Biochemical and …, 1999 - Elsevier
Dichloroacetate (DCA) inhibits its own metabolism and is converted to glyoxylate by glutathione
S-transferase ζ (GSTz). GSTz is identical to maleylacetoacetate isomerase, an enzyme …

Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate

AL Shroads, T Langaee, BS Coats… - The Journal of …, 2012 - Wiley Online Library
Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic
medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/…

Peripheral neuropathy in rats exposed to dichloroacetate

…, LM Mizisin, BR Torres, AL Shroads… - … of Neuropathology & …, 2009 - academic.oup.com
The use of dichloroacetate (DCA) for treating patients with mitochondrial diseases is limited
by the induction of peripheral neuropathy. The mechanisms of DCA-induced neuropathy are …

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children

…, NV Nagaraja, AL Shroads… - The Journal of …, 2003 - Wiley Online Library
The authors conducted a randomized, double‐blind, placebo‐controlled trial of intravenous
dichloroacetate (DCA) for the purpose of treating lactic acidosis in 124 West African children …

The heme precursor delta‐aminolevulinate blocks peripheral myelin formation

…, AL Shroads, PW Stacpoole, L Notterpek - Journal of …, 2008 - Wiley Online Library
Delta‐aminolevulinic acid (δ‐ALA) is a heme precursor implicated in neurological complications
associated with porphyria and tyrosinemia type I. Delta‐ALA is also elevated in the …

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal

X Guo, V Dixit, H Liu, AL Shroads, GN Henderson… - Drug metabolism and …, 2006 - ASPET
Dichloroacetate (DCA) is an investigational drug for certain metabolic disorders, a by-product
of water chlorination and a metabolite of certain industrial solvents and drugs. DCA is …

Population pharmacokinetics of intramuscular quinine in children with severe malaria

…, D Ansong, A Owusu-Ofori, AL Shroads… - Antimicrobial agents …, 2001 - Am Soc Microbiol
We present the first population pharmacokinetic analysis of quinine in patients with
Plasmodium falciparum malaria. Ghanaian children (n = 120; aged 12 months to 10 years) with …