[PDF][PDF] High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32

A Temme, A Buchmann, HD Gabriel, E Nelles… - Current Biology, 1997 - cell.com
Connexins are subunits of gap junction channels, which mediate the direct transfer of ions,
second messenger molecules and other metabolites between contacting cells. Gap junctions …

Differential gene expression in periportal and perivenous mouse hepatocytes

…, C Köhle, S Hailfinger, M Bonin, A Buchmann… - The FEBS …, 2006 - Wiley Online Library
Hepatocytes located in the periportal and perivenous zones of the liver lobule show remarkable
differences in the levels and activities of various enzymes and other proteins. To analyze …

Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.

K Brown, A Buchmann… - Proceedings of the …, 1990 - National Acad Sciences
A number of mouse skin tumors initiated by the carcinogens N-methyl-N'-nitro-N-nitrosoguanidine
(MNNG), methylnitrosourea (MNU), 3-methylcholanthrene (MCA), and 7,12-…

A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice

O Moennikes, S Loeppen, A Buchmann, P Andersson… - Cancer research, 2004 - AACR
The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription
factor regulating transcription of a battery of genes encoding enzymes involved in drug …

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of β-catenin-mutated mouse liver tumors

H Aydinlik, TD Nguyen, O Moennikes, A Buchmann… - Oncogene, 2001 - nature.com
Tumor promoters are non-mutagenic chemicals which increase the probability of cancer by
accelerating the clonal expansion of cells transformed during tumor initiation. Phenobarbital (…

[PDF][PDF] Zonal gene expression in murine liver: lessons from tumors

…, M Jaworski, A Braeuning, A Buchmann… - …, 2006 - Wiley Online Library
Gene expression in hepatocytes within the liver lobule is differentially regulated along the
portal to central axis; however, the mechanisms governing the processes of zonation within …

Aristolochic Acid Activates ras Genes in Rat Tumors at Deoxyadenosine Residues

…, J Lyons, HR Scherf, W Pfau, A Buchmann… - Cancer research, 1990 - AACR
Aristolochic acid I (AAI), a nitrophenanthrene derivative, is the major component of the
carcinogenic plant extract aristolochic acid, which has been used as a medicine since antiquity. …

Overexpression of glutamine synthetase is associated with β-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital

…, F Gaunitz, R Gebhardt, R Kurek, A Buchmann… - Cancer research, 2002 - AACR
Phenobarbital (PB) is an antiepileptic drug that promotes hepatocarcinogenesis in rodents
when administered subsequent to an initiating carcinogen like N-nitrosodiethylamine (DEN). …

Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis.

A Buchmann, R Bauer-Hofmann… - Proceedings of the …, 1991 - National Acad Sciences
The frequency and pattern of mutations at codon 61 of the c-Ha-ras gene have been analyzed
in 195 liver tumors and 132 precancerous liver lesions from various rodent strains with …

Expression of hypoxia-inducible genes in tumor cells

…, P Maurer, B Weber, J Reichert, A Buchmann… - Journal of cancer …, 1998 - Springer
Tumor tissue oxygenation impacts on proliferation of cancer cells and their sensitivity
towards radio- and chemotherapy. Under low oxygen, mammalian cells show an adaptive …