Cell-penetrating peptides (CPPs) are versatile tools for the intracellular delivery of various
biomolecules, including siRNA. Recently, CPPs were introduced that showed greatly …

… Author links open overlay panel Dirk van den Brand a b , Mark AJ Gorris c , Alexander H.
van Asbeck a 1 , Emma Palmen a , Inge Ebisch d , Harry Dolstra e , Mattias Hällbrink f , Leon …

Cisplatin is a cytostatic drug used for treatment of solid organ tumors. The main adverse
effect is organic cation transporter 2 (OCT2)–mediated nephrotoxicity, observed in 30% of …

The successful application of gene therapy relies on the development of safe and efficient
delivery vectors. Cationic polymers such as cell-penetrating peptides (CPPs) can condense …

RNA has enormous potential as a therapeutic, yet, the successful application depends on
efficient delivery strategies. In this study, we demonstrate that a designed artificial viral coat …

… Author links open overlay panel Alexander H. van Asbeck a 1 , Jürgen Dieker a 1 , Milou …
We propose 2–8 h as the ideal timespan with respect to circulation and degradation at least for …

The formation of noncovalent complexes by mixing of positively charged polymers with
negatively charged oligonucleotides (ONs) is a widely explored concept in nanomedicine to …

Messenger RNA is rapidly gaining significance as a therapeutic modality. Here, we address
the dependence of dose–response functions on the type of delivery vehicle, cell line, and …

Sepsis-associated acute kidney injury is a multifactorial syndrome in which inflammation
and renal microcirculatory dysfunction play a profound role. Subsequently, renal tubule …

Cationic cell-penetrating peptides spontaneously associate with negatively charged
oligonucleotides to form submicron nanoparticles, so-called polyplexes. Contact with cells leads to …