User profiles for Alexander Poltorak
 | Alexander PoltorakTufts University Verified email at tufts.edu Cited by 16465 |
Genetic and physical mapping of theLpsLocus: identification of the Toll-4 receptor as a candidate gene in the critical region
A Poltorak, I Smirnova, X He, MY Liu… - Blood Cells, Molecules …, 1998 - Elsevier
On the basis of 2093 meioses analyzed in two separate intraspecific backcrosses, the location
of the mouseLps d mutation was circumscribed to a genetic interval 0.9 cM in size. A total …
of the mouseLps d mutation was circumscribed to a genetic interval 0.9 cM in size. A total …
Three novel mammalian toll-like receptors: gene structure, expression, and evolution.
X Du, A Poltorak, Y Wei, B Beutler - European cytokine network, 2000 - jle.com
1. Anderson KV, Jurgens G, Nusslein-Volhard C. 1985. Establishment of dorsal-ventral
polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42: …
polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42: …
Cutting edge: activation of STING in T cells induces type I IFN responses and cell death
Stimulator of interferon genes (STING) was initially described as a sensor of intracellular
bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently …
bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently …
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
A Poltorak, X He, I Smirnova, MY Liu, CV Huffel, X Du… - Science, 1998 - science.org
Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction
in C3H/HeJ and C57BL/10ScCr mice, rendering them resistant to endotoxin yet highly …
in C3H/HeJ and C57BL/10ScCr mice, rendering them resistant to endotoxin yet highly …
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby …
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby …
[PDF][PDF] RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by toll-like receptor 4
Macrophages are a crucial component of the innate immune system in sensing pathogens
and promoting local and systemic inflammation. RIPK1 and RIPK3 are homologous kinases, …
and promoting local and systemic inflammation. RIPK1 and RIPK3 are homologous kinases, …
[HTML][HTML] PU. 1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
M Rehli, A Poltorak, L Schwarzfischer… - Journal of Biological …, 2000 - ASBMB
The protein product of the Toll-like receptor (TLR) 4 gene has been implicated in the signal
transduction events induced by lipopolysaccharide (LPS). In mice, destructive mutations …
transduction events induced by lipopolysaccharide (LPS). In mice, destructive mutations …
Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies
B Beutler, X Du, A Poltorak - Journal of endotoxin research, 2001 - journals.sagepub.com
One of the most interesting questions confronting the LPS signal transduction field during the
1990s concerned the identity of a postulated co-receptor for LPS. In 1990, LPS was shown …
1990s concerned the identity of a postulated co-receptor for LPS. In 1990, LPS was shown …
Sepsis and evolution of the innate immune response
B Beutler, A Poltorak - Critical care medicine, 2001 - journals.lww.com
… Poltorak A, Smirnova I, He X, et al: Genetic and physical mapping of the Lps locus-identification
of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis 1998; 24 …
of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis 1998; 24 …
[HTML][HTML] Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)
I Smirnova, A Poltorak, EKL Chan, C McBride… - Genome biology, 2000 - Springer
Background Differences in responses to bacterial surface lipopolysaccharides (LPSs) are
apparent between and within mammalian species. It has been shown in mice that resistance …
apparent between and within mammalian species. It has been shown in mice that resistance …