The cytochrome P450 gene superfamily encodes many isoforms that are unusual in the variety
of chemical reactions catalyzed and the number of substrates attacked. The latter include …

Cytoehrome P450, the most versatile biological catalyst known, was originally named as a
pigment having a carbon monoxide difference spectrum at about 450 nm and no known …

A hypervalent iron-oxene species has been widely proposed as the “active oxygen” in
cytochrome P450 (P450)-catalyzed reactions. We recently examined the effect of mutation of the …

P450 cytochromes (P450) catalyze many types of oxidative reactions, including the conversion
of olefinic substrates to epoxides by oxygen insertion. In some instances epoxidation …

Oxidation of the mechanistic probes trans,trans-2-methoxy-3-phenylmethylcyclopropane
and methylcubane by six cytochrome P450 isozymes has been studied. The probes …

Tofacitinib is a novel, oral Janus kinase inhibitor. The objectives of this study were to
summarize the pharmacokinetics and metabolism of tofacitinib in humans, including clearance …

The therapeutic benefits of the antidepressant nefazodone have been hampered by several
cases of acute hepatotoxicity/liver failure. Although the mechanism of hepatotoxicity remains …

Revised Manuscript Received January 19, 1995® abstract: The origin of charge transfer bands
that develop on reaction of Old Yellow Enzyme with,/3-unsaturated cyclic ketonessuch as …

Clinically observed drug interactions with cytochrome P450 (P450) enzymes have increased
the need to assess drug interactions of new chemical entities early in the discovery process…

The 3-unsubstituted isoxazole ring in the anti-inflammatory drug leflunomide undergoes a
unique N–O bond cleavage to the active α-cyanoenol metabolite A771726, which resides in …