Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
The objectives of the following investigation were (1) development of a physiologically
based pharmacokinetic (PBPK) model capable of characterizing the plasma and tissue …
based pharmacokinetic (PBPK) model capable of characterizing the plasma and tissue …
Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and …
Tissue vs. plasma concentration profiles have been generated from a physiologically-based
pharmacokinetic model of monoclonal antibody (mAb). Based on the profiles, we …
pharmacokinetic model of monoclonal antibody (mAb). Based on the profiles, we …
The Desert" Kites" of the Badiyat Esh-Sham and North Arabia
S Helms, A Betts - Paléorient, 1987 - JSTOR
Archaeological investigations into the steppic regions of the Near East have only recently
been systematized in controlled surveys and excavations. Prior to this information regarding …
been systematized in controlled surveys and excavations. Prior to this information regarding …
Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin
To build a multiscale mechanism based pharmacokinetic–pharmacodynamic (PK/PD)
model for antibody drug conjugates (ADCs), using brentuximab-vedotin as an example, for …
model for antibody drug conjugates (ADCs), using brentuximab-vedotin as an example, for …
The origins of wheat in China and potential pathways for its introduction: A review
Today in China, hexaploid wheat (Triticum aestivum – common wheat or bread wheat) is
one of the major staple food crops. The other key cereal staples – rice, foxtail millet and …
one of the major staple food crops. The other key cereal staples – rice, foxtail millet and …
[BOOK][B] The Harra and the Hamad: excavations and explorations in Eastern Jordan
AVG Betts - 1999 - books.google.com
Eastern Jordan is divided environmentally into two sectors: the rocky basalt Harra to the
west and the open gravel plains of the Hamad to the east. This is the first in a series of three …
west and the open gravel plains of the Hamad to the east. This is the first in a series of three …
A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions
Disease relapse after treatment is common in triple-negative breast cancer (TNBC), ovarian
cancer (OVCA), and non–small cell lung cancer (NSCLC). Therapies that target tumor-…
cancer (OVCA), and non–small cell lung cancer (NSCLC). Therapies that target tumor-…
The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis
AM Betts, TH Clark, J Yang, JL Treadway, M Li… - … of Pharmacology and …, 2010 - ASPET
PF-04840082 is a humanized prototype anti-Dickkopf-1 (Dkk-1) immunoglobulin isotype G
2 (IgG 2 ) antibody for the treatment of osteoporosis. In vitro, PF-04840082 binds to human, …
2 (IgG 2 ) antibody for the treatment of osteoporosis. In vitro, PF-04840082 binds to human, …
Determination of cellular processing rates for a trastuzumab-maytansinoid antibody-drug conjugate (ADC) highlights key parameters for ADC design
Antibody-drug conjugates (ADCs) are a promising class of cancer therapeutics that combine
the specificity of antibodies with the cytotoxic effects of payload drugs. A quantitative …
the specificity of antibodies with the cytotoxic effects of payload drugs. A quantitative …
Adunqiaolu: new evidence for the Andronovo in Xinjiang, China
Bronze Age social and cultural interconnections across the Eurasian steppe are the subject
of much current debate. A particularly significant place is occupied by the Andronovo Culture …
of much current debate. A particularly significant place is occupied by the Andronovo Culture …