Interindividual variability in cytochrome P450–mediated drug metabolism
TS Tracy, AS Chaudhry, B Prasad, KE Thummel… - Drug Metabolism and …, 2016 - ASPET
The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human
drug metabolism. Alterations in the expression and/or activity of these enzymes result in …
drug metabolism. Alterations in the expression and/or activity of these enzymes result in …
Hepatic abundance and activity of androgen-and drug-metabolizing enzyme UGT2B17 are associated with genotype, age, and sex
The major objective of this study was to investigate the association of genetic and
nongenetic factors with variability in protein abundance and in vitro activity of the androgen-…
nongenetic factors with variability in protein abundance and in vitro activity of the androgen-…
[HTML][HTML] Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content
Y Shirasaka, AS Chaudhry, M McDonald… - The …, 2016 - nature.com
Large interindividual variability has been observed in the metabolism of CYP2C19
substrates in vivo. The study aimed to evaluate sources of this variability in CYP2C19 activity, …
substrates in vivo. The study aimed to evaluate sources of this variability in CYP2C19 activity, …
Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability
25-Hydroxyvitamin D 3 (25OHD 3 ) is used as a clinical biomarker for assessment of vitamin
D status. Blood levels of 25OHD 3 represent a balance between its formation rate and …
D status. Blood levels of 25OHD 3 represent a balance between its formation rate and …
Genetic and nongenetic factors associated with protein abundance of flavin-containing monooxygenase 3 in human liver
Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of
nucleophilic heteroatom (eg, N or S)-containing xenobiotics (eg, amphetamine, sulindac, …
nucleophilic heteroatom (eg, N or S)-containing xenobiotics (eg, amphetamine, sulindac, …
CYP2C9* 1B promoter polymorphisms, in linkage with CYP2C19* 2, affect phenytoin autoinduction of clearance and maintenance dose
AS Chaudhry, TJ Urban, JK Lamba, AK Birnbaum… - … of Pharmacology and …, 2010 - ASPET
The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and
wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 …
wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 …
The CYP2C19 intron 2 branch point SNP is the ancestral polymorphism contributing to the poor metabolizer phenotype in livers with CYP2C19* 35 and CYP2C19* 2 …
CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative
mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the …
mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the …
[HTML][HTML] Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines
…, CQ Simmons, A Konkashbaev, AS Chaudhry… - The …, 2017 - nature.com
Variation in the expression level and activity of genes involved in drug disposition and action
(‘pharmacogenes’) can affect drug response and toxicity, especially when in tissues of …
(‘pharmacogenes’) can affect drug response and toxicity, especially when in tissues of …
Ontogeny and sorafenib metabolism
…, L Li, D Finkelstein, A Gibson, AS Chaudhry… - Clinical Cancer …, 2012 - AACR
Purpose: To investigate the role of ontogeny in sorafenib metabolism to the equipotent active
metabolite sorafenib N-oxide. Experimental Design: Steady-state pharmacokinetic studies …
metabolite sorafenib N-oxide. Experimental Design: Steady-state pharmacokinetic studies …
[PDF][PDF] Genetic effects on liver chromatin accessibility identify disease regulatory variants
…, JP Didion, AS Chaudhry, BB Barnabas, S Black… - The American Journal of …, 2021 - cell.com
Identifying the molecular mechanisms by which genome-wide association study (GWAS)
loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) …
loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) …