Interindividual variability in cytochrome P450–mediated drug metabolism

TS Tracy, AS Chaudhry, B Prasad, KE Thummel… - Drug Metabolism and …, 2016 - ASPET
The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human
drug metabolism. Alterations in the expression and/or activity of these enzymes result in …

Hepatic abundance and activity of androgen-and drug-metabolizing enzyme UGT2B17 are associated with genotype, age, and sex

…, S Lee, KG Claw, A Mehrotra, AS Chaudhry… - Drug Metabolism and …, 2018 - ASPET
The major objective of this study was to investigate the association of genetic and
nongenetic factors with variability in protein abundance and in vitro activity of the androgen-…

[HTML][HTML] Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content

Y Shirasaka, AS Chaudhry, M McDonald… - The …, 2016 - nature.com
Large interindividual variability has been observed in the metabolism of CYP2C19
substrates in vivo. The study aimed to evaluate sources of this variability in CYP2C19 activity, …

Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability

…, NJ Koszewski, JP Goff, RL Horst, AS Chaudhry… - …, 2014 - academic.oup.com
25-Hydroxyvitamin D 3 (25OHD 3 ) is used as a clinical biomarker for assessment of vitamin
D status. Blood levels of 25OHD 3 represent a balance between its formation rate and …

Genetic and nongenetic factors associated with protein abundance of flavin-containing monooxygenase 3 in human liver

…, DK Bhatt, CK Yeung, KG Claw, AS Chaudhry… - … of Pharmacology and …, 2017 - ASPET
Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of
nucleophilic heteroatom (eg, N or S)-containing xenobiotics (eg, amphetamine, sulindac, …

CYP2C9* 1B promoter polymorphisms, in linkage with CYP2C19* 2, affect phenytoin autoinduction of clearance and maintenance dose

AS Chaudhry, TJ Urban, JK Lamba, AK Birnbaum… - … of Pharmacology and …, 2010 - ASPET
The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and
wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 …

The CYP2C19 intron 2 branch point SNP is the ancestral polymorphism contributing to the poor metabolizer phenotype in livers with CYP2C19* 35 and CYP2C19* 2 …

AS Chaudhry, B Prasad, Y Shirasaka, A Fohner… - Drug Metabolism and …, 2015 - ASPET
CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative
mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the …

[HTML][HTML] Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines

…, CQ Simmons, A Konkashbaev, AS Chaudhry… - The …, 2017 - nature.com
Variation in the expression level and activity of genes involved in drug disposition and action
(‘pharmacogenes’) can affect drug response and toxicity, especially when in tissues of …

Ontogeny and sorafenib metabolism

…, L Li, D Finkelstein, A Gibson, AS Chaudhry… - Clinical Cancer …, 2012 - AACR
Purpose: To investigate the role of ontogeny in sorafenib metabolism to the equipotent active
metabolite sorafenib N-oxide. Experimental Design: Steady-state pharmacokinetic studies …

[PDF][PDF] Genetic effects on liver chromatin accessibility identify disease regulatory variants

…, JP Didion, AS Chaudhry, BB Barnabas, S Black… - The American Journal of …, 2021 - cell.com
Identifying the molecular mechanisms by which genome-wide association study (GWAS)
loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) …