Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
…, DJ Ehresman, JW Froehlich, AM Seacat… - Environmental …, 2007 - ehp.niehs.nih.gov
Background The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS),
and perfluorooctanoate (PFOA) has been reported in humans and wildlife. …
and perfluorooctanoate (PFOA) has been reported in humans and wildlife. …
The toxicology of perfluorooctanoate
…, GW Olsen, JC O'Connor, AM Seacat… - Critical reviews in …, 2004 - Taylor & Francis
PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical
effects characteristic of PPAR agonists. These effects include increased β-oxidation of fatty …
effects characteristic of PPAR agonists. These effects include increased β-oxidation of fatty …
Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys
AM Seacat, PJ Thomford, KJ Hansen… - Toxicological …, 2002 - academic.oup.com
This study was conducted to determine the earliest measurable response of primates to low-level
perfluorooctanesulfonate (PFOS) exposure and to provide information to reduce …
perfluorooctanesulfonate (PFOS) exposure and to provide information to reduce …
Interactions of flurochemicals with rat liver fatty acid-binding protein
…, KJ Hansen, NM Bass, JL Butenhoff, AM Seacat - Toxicology, 2002 - Elsevier
Liver-fatty acid binding protein (L-FABP) is an abundant intracellular lipid-carrier protein. The
hypothesis that perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and certain …
hypothesis that perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and certain …
Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
AM Seacat, PJ Thomford, KJ Hansen, LA Clemen… - Toxicology, 2003 - Elsevier
Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at
low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating …
low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating …
Biotransformation of N-Ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by Rat Liver Microsomes, Cytosol, and Slices and by Expressed Rat and Human …
L Xu, DM Krenitsky, AM Seacat… - Chemical research in …, 2004 - ACS Publications
Perfluorooctanesulfonic acid (PFOS) and its derivatives have been used in a range of
industrial and commercial applications, including the manufacture of surfactants, adhesives, …
industrial and commercial applications, including the manufacture of surfactants, adhesives, …
trans-Activation of PPARα and Induction of PPARα Target Genes by Perfluorooctane-Based Chemicals
…, FL DeRoos, JL Butenhoff, AM Seacat… - Toxicological …, 2004 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription
factors that activate target genes involved in lipid metabolism, energy homeostasis, and cell …
factors that activate target genes involved in lipid metabolism, energy homeostasis, and cell …
Increased oxidative DNA damage in livers of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats
AM Tritscher, AM Seacat, JD Yager, JD Groopman… - Cancer letters, 1996 - Elsevier
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a more potent hepatocarcinogen in female
than in male or ovariectomized rats. A possible mechanism for this increased sensitivity is …
than in male or ovariectomized rats. A possible mechanism for this increased sensitivity is …
ESR identification of free radicals formed from the oxidation of catechol estrogens by Cu2+
AM Seacat, P Kuppusamy, JL Zweier… - Archives of biochemistry …, 1997 - Elsevier
Catechol estrogens are genotoxic, indirectly through redox cycling mechanisms leading to
oxidative DNA damage and directly by formation of quinone–DNA adducts. Previously, we …
oxidative DNA damage and directly by formation of quinone–DNA adducts. Previously, we …
N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases
L Xu, DM Krenitsky, AM Seacat, JL Butenhoff… - Drug metabolism and …, 2006 - ASPET
N-Alkylperfluorooctanesulfonamides have been used in a range of industrial and
commercial applications. Perfluorooctanesulfonamide (FOSA) is a major metabolite of N-…
commercial applications. Perfluorooctanesulfonamide (FOSA) is a major metabolite of N-…