On the freshwater ecotoxicity and biodegradation properties of some common ionic liquids

AS Wells, VT Coombe - Organic Process Research & …, 2006 - ACS Publications
Ecotoxicological tests, using OECD standard methods on some ionic liquids, have revealed
that several have very high toxicity towards freshwater algae and the freshwater invertebrate …

Future trends for green chemistry in the pharmaceutical industry

PJ Dunn, AS Wells, MT Williams - Green Chemistry in the …, 2010 - Wiley Online Library
In this chapter, the authors would like to look at the current state of Green Chemistry, and then
look forward to what will happen in this arena over the next 20 years. The pharmaceutical …

Survey of Solvent Usage in Papers Published in Organic Process Research & Development 1997–2012

…, PJ Dunn, JD Hayler, AS Wells - … Process Research & …, 2015 - ACS Publications
A survey of solvent usage for papers published in Organic Process Research & Development
has been carried out for the years 1997–2012. Three solvent categories were studied: (i) …

Use of Enzymes in the Manufacture of Active Pharmaceutical Ingredients A Science and Safety-Based Approach To Ensure Patient Safety and Drug Quality

AS Wells, GL Finch, PC Michels… - … Process Research & …, 2012 - ACS Publications
A significant number of marketed pharmaceuticals contain active pharmaceutical ingredients
that are manufactured in part using biocatalysis as a key enabling technology. The …

The PMI Predictor app to enable green-by-design chemical synthesis

A Borovika, J Albrecht, J Li, AS Wells, C Briddell… - Nature …, 2019 - nature.com
The development of sustainable processes for the synthesis of new clinical candidates is a
priority for every pharmaceutical company. The ultimate efficiency of a molecule’s synthesis …

The development of a manufacturing route for the GPIIb/IIIa receptor antagonist SB-214857-A. Part 2: conversion of the key intermediate SB-235349 to SB-214857-A

…, SC Passey, TC Walsgrove, AS Wells - … process research & …, 2003 - ACS Publications
The process development to the manufacturing route to (2S)-7-([4,4‘-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic
acid hydrochloride (SB…

Use of ω-transaminase enzyme chemistry in the synthesis of a JAK2 kinase inhibitor

…, C Squire, S Tomasi, D Watt, AS Wells - … Process Research & …, 2013 - ACS Publications
ω-Transaminase enzyme chemistry provides an excellent methodology to build synthetically
useful chiral amines from their corresponding ketones. An application of this methodology, …

Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω-Transaminase Biocatalyst in a Two-Phase System

…, O May, C Squire, H Straatman, AS Wells - … Process Research & …, 2013 - ACS Publications
Screening of 60 transaminases using three different amine donors found that the ω-transaminase
from Vibrio fluvialis together with (S)-α-methylbenzylamine to be the most promising …

A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A

IP Andrews, RJ Atkins, NF Badham, RK Bellingham… - Tetrahedron …, 2001 - Elsevier
A new synthesis of lotrafiban SB-214857-A is reported. The key steps are the preparation of
racemic (4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid …

Synthesis of SB-214857 using copper catalysed amination of arylbromides with L-aspartic acid

…, JF Hayes, HM Sheldrake, PW Sheldrake, AS Wells - Synlett, 2001 - thieme-connect.com
WellsWells, AS … IR 1740, 1650, 1580, 1510 and 1430 cm-1, 1H NMR (CDCl3): d
2.91 (dd, ABX, J = 6.2, 16.0 Hz, 1H), 2.97 (dd, ABX, J = 6.2, 16.1 Hz, 1H), 3.71 (s, 3H), 3.78 (s …