[HTML][HTML] Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

E Saunier, S Antonio, A Regazzetti, N Auzeil… - Scientific reports, 2017 - nature.com
Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory
and anti-proliferative properties potentially beneficial in cancers, in particular in the …

Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite

…, N Auzeil, F Boulinguez, H Saighi, A Regazzetti… - Biochemical …, 2011 - Elsevier
Although the natural flavonoid fisetin (3,3′,4′,7-tetrahydroxyflavone) has been recently
identified as an anticancer agent with antiangiogenic properties in mice, its in vivo …

Design, synthesis and biological evaluation of novel 1, 2, 3-triazole linked coumarinopyrazole conjugates as potent anticholinesterase, anti-5-lipoxygenase, anti …

S Chekir, M Debbabi, A Regazzetti, D Dargère… - Bioorganic …, 2018 - Elsevier
A series of new 1,2,3-triazole linked coumarinopyrazole conjugates 4a-e and 5a-e have
been synthesized via the Copper(I)-catalysed Alkyne-Azide Cycloaddition (CuAAC). Going …

P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?

E Olivier, M Dutot, A Regazzetti, T Leguillier, D Dargère… - Biochimie, 2016 - Elsevier
Age-related macular degeneration (AMD) is the most common cause of severe vision loss
worldwide. Amyloid β involvement in degenerative diseases such as AMD is well known and …

Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: New insights in dry eye disease

R Magny, K Kessal, A Regazzetti, AB Yedder… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Dry eye disease (DED) is a multifactorial chronic inflammatory disease of the ocular surface
characterized by tear film instability, hyperosmolarity, cell damage and inflammation. …

Lipidomic analysis of human corneal epithelial cells exposed to ocular irritants highlights the role of phospholipid and sphingolipid metabolisms in detergent toxicity …

R Magny, N Auzeil, E Olivier, K Kessal, A Regazzetti… - Biochimie, 2020 - Elsevier
Detergent chemicals, widely used in household products, in pharmaceutical, medical,
cosmetic and industrial fields, have been linked to side effects and involved in several eye …

[HTML][HTML] Neuronal cholesterol accumulation induced by Cyp46a1 down-regulation in mouse hippocampus disrupts brain lipid homeostasis

S Ayciriex, F Djelti, S Alves, A Regazzetti… - Frontiers in molecular …, 2017 - frontiersin.org
Impairment in cholesterol metabolism is associated with many neurodegenerative disorders
including Alzheimer's disease (AD). However, the lipid alterations underlying …

25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways

E Olivier, M Dutot, A Regazzetti, O Laprévote… - Chemistry and physics of …, 2017 - Elsevier
Degenerative diseases are characterized by both cell death and inflammation, which involve
different pathways such as apoptosis and pyroptosis. Oxysterols, oxidized derivatives of …

[HTML][HTML] Lipid annotation by combination of UHPLC-HRMS (MS), molecular networking, and retention time prediction: application to a lipidomic study of in vitro models …

R Magny, A Regazzetti, K Kessal, G Genta-Jouve… - Metabolites, 2020 - mdpi.com
Annotation of lipids in untargeted lipidomic analysis remains challenging and a systematic
approach needs to be developed to organize important datasets with the help of bioinformatic …

[HTML][HTML] Lipid deregulation in UV irradiated skin cells: Role of 25-hydroxycholesterol in keratinocyte differentiation during photoaging

E Olivier, M Dutot, A Regazzetti, D Dargère… - The Journal of steroid …, 2017 - Elsevier
Skin photoaging due to UV irradiation is a degenerative process that appears more and more
as a growing concern. Lipids, including oxysterols, are involved in degenerative processes…