Lipopolysaccharide (LPS) may cause sepsis when it enters the blood circulation. The toxic
moiety of LPS is the well-preserved lipid A part. Lipid A contains two phosphate groups …

Purpose Activation of tubular epithelial cells by transforming growth factor-beta (TGF-β) plays
an important role in the pathogenesis of renal tubulointerstitial fibrosis. We developed a …

In previous studies, we have demonstrated that the low molecular weight protein lysozyme
can be used as a renal-selective drug carrier for delivery of the angiotensin-converting …

Purpose Delivery of apoptosis-inducing compounds to hepatic stellate cells (HSC) may be
an effective strategy to reverse liver fibrosis. The aim of this study was therefore to examine …

Cytokines are considered a promising immunotherapy for chronic diseases, because of their
potency and fundamental roles in pathological processes. However, their therapeutic use is …

In fibrotic livers, collagen producing hepatic stellate cells (HSC) represent a major target for
antifibrotic therapies. We designed liposomes with surface-coupled mannose 6-phosphate …

Specific delivery of therapeutic entities to tumor endothelium and to tumor cells is considered
an attractive strategy to battle cancer without the typical side effects of conventional cancer …

… Scherphof Dirk KF Meijer Annemiek van Loenen-Weemaes Catharina Reker-Smit … α-S M A
sta … K, Lazou JM, Stange G, Van De Winkel M, De Bleser P. Purification of rat hepatic stellate …

… Catharina Reker-Smit, Eduard Post and Annemiek M. van Loenen-Weemaes are acknowledged
for their excellent technical assistance. Authors also thank JH Pol from the Department …