[HTML][HTML] Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase

HM Peng, Y Morishima, GJ Jenkins, AY Dunbar… - Journal of Biological …, 2004 - ASBMB
It is established that neuronal nitric-oxide synthase (nNOS) is ubiquitylated and proteasomally
degraded. The proteasomal degradation of nNOS is enhanced by suicide inactivation of …

[HTML][HTML] The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase

…, Y Morishima, PJM Murphy, AY Dunbar… - Journal of Biological …, 2004 - ASBMB
Like other nitric-oxide synthase (NOS) enzymes, neuronal NOS (nNOS) turnover and activity
are regulated by the ubiquitous protein chaperone hsp90. We have shown previously that …

Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones

Y Osawa, ER Lowe, AC Everett, AY Dunbar… - … of Pharmacology and …, 2003 - ASPET
Nitric oxide synthase (NOS) is a highly regulated enzyme that produces nitric oxide, a critical
messenger in many physiological processes. In this perspective, we explore the role of …

Generation and characterization of a novel Cyp2a (4/5) bgs-null mouse model

Y Wei, L Li, X Zhou, QY Zhang, A Dunbar, F Liu… - Drug Metabolism and …, 2013 - ASPET
Knockout mouse models targeting various cytochrome P450 (P450 or CYP) genes are
valuable for determining P450’s biologic functions, including roles in drug metabolism and …

Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis

AY Dunbar, Y Kamada, GJ Jenkins, ER Lowe… - Molecular …, 2004 - ASPET
It is established that neuronal NO synthase (nNOS) is ubiquitinated and proteasomally degraded.
The metabolism-based inactivation of nNOS and the inhibition of heat shock protein 90 …

Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke

…, AC Everett, SS Billecke, Y Kamada, AY Dunbar… - Drug metabolism and …, 2003 - ASPET
It has been shown that administration of cigarette smoke to rats leads to loss of neuronal
nitric-oxide synthase (nNOS) activity and nNOS protein in penile tissue. The exact mechanism …

Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes

ER Lowe, AC Everett, AJ Lee, M Lau, AY Dunbar… - Drug metabolism and …, 2005 - ASPET
Smoking causes a dysfunction in endothelial nitric-oxide synthase (eNOS), which is ameliorated,
in part, by administration of tetrahydrobiopterin (BH 4 ). The exact mechanism by which …

Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase

Y Kamada, GJ Jenkins, M Lau, AY Dunbar… - Molecular brain …, 2005 - Elsevier
Tetrahydrobiopterin is a necessary cofactor for the synthesis of nitric oxide by the
hemeprotein enzyme, NO-synthase (NOS). It is widely thought that inadequate levels of …

Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo

AY Dunbar, GJ Jenkins, S Jianmongkol… - Drug metabolism and …, 2006 - ASPET
It is established that guanabenz inhibits neuronal nitric-oxide (NO) synthase (nNOS) and
causes the enhanced proteasomal degradation of nNOS in vivo. Although the time- and NADPH…

Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants

ER Lowe, AC Everett, M Lau, AY Dunbar, D Michener… - Phytomedicine, 2007 - Elsevier
NO-synthase (NOS) is a heme-containing enzyme that catalyzes the oxidation of l-arginine
to nitric oxide, an important cellular signaling molecule. Recently, it was found that aqueous …