Background This study evaluates the relationship between cytochrome P450 (CYP) 3A5
genotype and vincristine‐induced peripheral neuropathy (VIPN) in children with precursor B …

All-trans-retinoic acid (atRA) is an important signaling molecule in all chordates. The cytochrome
P450 enzymes CYP26 are believed to partially regulate cellular concentrations of atRA …

All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription
via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites …

Cannabis is used widely in the United States, both recreationally and for medical purposes.
Current methods for analysis of cannabinoids in human biological specimens rely on …

Vinorelbine is a semisynthetic vinca alkaloid used in the treatment of advanced breast and
non-small cell lung cancers. Vincristine, a related vinca alkaloid, is 9-fold more efficiently …

All-trans-retinoic acid (atRA), the major active metabolite of vitamin A, plays a role in many
biological processes, including maintenance of epithelia, immunity, and fertility and regulation …

Background Nausea and vomiting of pregnancy (NVP) is a common condition. The objective
of this study was to evaluate the association between response to antiemetics in the …

Domoic acid (DA), a neurotoxin, is produced by marine algae and has caused toxications
worldwide in animals and humans. However, the toxicokinetics of DA have not been fully …

There is considerable evidence that drug disposition is altered during human pregnancy
and based on probe drug studies, CYP2D6 activity increases during human pregnancy. The …

… , Dr Ariel Topletz and Dr Guo Zhong conducted the experiments and all three authors wrote
the manuscript. Parts of the work in this manuscript were included in Dr Ariel Topletz’s PhD …