Discovery of riociguat (BAY 63‐2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
…, E Bischoff, A Feurer, M Gerisch, A Kern… - ChemMedChem …, 2009 - Wiley Online Library
Direct stimulation of soluble guanylate cyclase (sGC) represents a promising therapeutic
strategy for the treatment of a range of diseases, including the severely disabling pulmonary …
strategy for the treatment of a range of diseases, including the severely disabling pulmonary …
Discovery of the soluble guanylate cyclase stimulator vericiguat (BAY 1021189) for the treatment of chronic heart failure
…, G Redlich, F Wunder, D Lang, A Kern… - Journal of medicinal …, 2017 - ACS Publications
The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently
introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding …
introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding …
Rhizocticin A, an antifungal phosphono-oligopeptide of Bacillus subtilis ATCC 6633: biological properties
M Kugler, W Loeffler, C Rapp, A Kern, G Jung - Archives of Microbiology, 1990 - Springer
Rhizocticin A, the main component of the antifungal, hydrophilic phosphono-oligopeptides
of Bacillus subtilis ATCC 6633, was used for sensitivity testing and experiments into the …
of Bacillus subtilis ATCC 6633, was used for sensitivity testing and experiments into the …
Discovery of the soluble guanylate cyclase activator runcaciguat (BAY 1101042)
…, T Mondritzki, H Tinel, A Knorr, A Kern… - Journal of Medicinal …, 2021 - ACS Publications
Herein we describe the discovery, mode of action, and preclinical characterization of the
soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of …
soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of …
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase
A Straub, J Benet-Buckholz, R Fröde, A Kern… - Bioorganic & medicinal …, 2002 - Elsevier
The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543
were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. …
were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. …
Metabolism of cerivastatin by human liver microsomes in vitro: characterization of primary metabolic pathways and of cytochrome P450 isozymes involved
…, P Fey, WK Kanhai, W Karl, A Kern… - Drug metabolism and …, 1997 - ASPET
Biotransformation of cerivastatin, a new cholesterol-lowering drug, by human liver microsomes
was investigated using the 14 C-labeled drug. Metabolite profiles were established by …
was investigated using the 14 C-labeled drug. Metabolite profiles were established by …
The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes: the current status: ECVAM Hepatocytes and Metabolically Competent …
…, J Doehmer, G Fabre, J Fry, A Kern… - Alternatives to …, 1999 - journals.sagepub.com
In this report, metabolically competent in vitro systems have been reviewed, in the context of
drug metabolising enzyme induction. Based on the experience of the scientists involved, a …
drug metabolising enzyme induction. Based on the experience of the scientists involved, a …
Biotransformation of Cerivastatin in Mice, Rats, and Dogsin vivo
…, R Angerbauer, WK Kanhai, W Karl, A Kern… - Drug Metabolism and …, 1998 - ASPET
Biotransformation of cerivastatin was investigated in mice, rats, and dogs in vivo using the
14 C-labeled drug. Marked species differences exist, both in pathways and extent of …
14 C-labeled drug. Marked species differences exist, both in pathways and extent of …
Absorption, distribution, metabolism and excretion of molidustat in healthy participants
S Lentini, D van der Mey, A Kern… - Basic & Clinical …, 2020 - Wiley Online Library
The absorption, distribution, metabolism and excretion of molidustat were investigated in
healthy male participants. In study 1, a mass balance study, radiolabelled molidustat 25 mg (…
healthy male participants. In study 1, a mass balance study, radiolabelled molidustat 25 mg (…
Metabolic products from microorganisms. 230 amiclenomycin-peptides, new antimetabolites of biotin. Taxonomy, fermentation and biological properties
…, H ZÄHNER, RG WERNER, A KERN… - The Journal of …, 1985 - jstage.jst.go.jp
… AR\\IIN KERN and GCNTHER JUN … 5) KERN, A.; U. KABATEK, G. JUNG, RG WERNER, NI. …