Liver is the primary source of numerous proteins that are critical for normal function of the
blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated …

Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative
functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg …

Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration.
We sought to identify features that characterize human Treg cells with these functions in …

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) is a surrogate marker of IR. We …

Intravascular fibrin clot formation follows a well-ordered series of reactions catalyzed by
thrombin cleavage of fibrinogen leading to fibrin polymerization and cross-linking by factor XIIIa (…

Non-alcoholic fatty liver disease is manifested by hepatic accumulation of triglycerides (TG)
and is commonly associated with metabolic syndrome. The isoprenoid farnesol (FOH) …

Background Blood coagulation protease activity is proposed to drive hepatic fibrosis through
activation of protease‐activated receptors (PARs). Whole‐body PAR‐1 deficiency reduces …

Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and
suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity …

CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells
can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-…

Engineered regulatory T cell (Treg cell) therapy is a promising strategy to treat patients
suffering from inflammatory diseases, autoimmunity, and transplant rejection. However, in many …