Purpose To establish a physiologically-based pharmacokinetic (PBPK) model for analyzing
the factors associated with side effects of irinotecan by using a computer-based virtual …

Modulation of CYP3A and/or P-gp function by several excipients has been reported. However,
relatively few studies have investigated their effects in humans. Therefore, the aim of this …

Bosentan is a substrate of hepatic uptake transporter organic anion–transporting
polypeptides (OATPs), and undergoes extensive hepatic metabolism by cytochrome P450 (P450), …

… Author links open overlay panel Nora Lee a b 1 , Kazuya Maeda c 1 , Shinya Fukizawa c ,
Ichiro Ieiri d , Atsuko Tomaru a , Hironobu Akao e , Kenji Takeda e , Mizuho Iwadare e , Osamu …

Oral sulfasalazine (SASP) is now used clinically as a probe substrate of a breast cancer
resistance protein (BCRP) activity; however the intestinal absorption characteristics of SASP are …

□ Spontaneous chemiluminescence associated with the cell injury was observed in the
isolated rat hepatocyte suspension during acetaminophen (APAP) metabolism, indicating the …

Ritonavir dramatically increases the bioavailability of a variety of concurrently administered
drugs by inhibition of metabolic enzymes and drug transporters. The purpose of this study …

To identify oral drugs that likely display nonlinear pharmacokinetics due to saturable
metabolism by intestinal CYP3A, our previous report using CYP3A substrate drugs proposed an …

Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction.
Factors that stimulate collateral formation are expected to have ameliorating effects on …

The feasibility of a novel catheter system of percutaneous transluminal cardiomyotomy and
valvulotomy was examined in anesthetized dogs. The system was composed of a guiding …