Phospholipase A 2 (PLA 2 ) enzymes are considered the primary source of arachidonic acid
for cyclooxygenase (COX)–mediated biosynthesis of prostaglandins. Here, we show that a …

Parkinson’s disease (PD) is the first and second most prevalent motor and neurodegenerative
disease, respectively. The clinical symptoms of PD result from a loss of midbrain …

In the ongoing effort of designing school contexts in support of proactive discipline, a range
of practices and theoretical frameworks have been advanced, from behaviorist approaches …

Huntington’s disease (HD) is caused by CAG repeat expansions in the (huntingtin htt) gene,
yielding proteins containing polyglutamine repeats that become misfolded and resist …

Parkinson’s Disease (PD) is a multi-system neurodegenerative disease where approximately
90% of cases are idiopathic. The remaining 10% of the cases can be traced to a genetic …

Invasive aspergillosis is a severe pneumonia that is usually fatal despite currently available
therapy. The disease disproportionately afflicts immunocompromised patients, indicating the …

Background Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent
enzymes, are involved in the regulation of neuronal survival. Indeed, SIRT1 has been …

This paper will introduce a whole‐school approach to regulating safe school communities,
based on principles of restorative justice. The idea is to move beyond regulatory formalism to …

HDAC4 is a Class II histone deacetylase (HDAC) that is highly expressed in the brain, but
whose functional significance in the brain is not known. We show that forced expression of …

Objective Aggregation of α‐synuclein (α‐syn) and α‐syn cytotoxicity are hallmarks of
sporadic and familial Parkinson disease (PD), with accumulating evidence that prefibrillar …