… Three oxidative metabolic pathways are involved in the systemic clearance of atomoxetine:
aromatic ring-hydroxylation, benzylic hydroxylation and N-demethylation. Aromatic ring-…

The 1980s through 1990s witnessed the widespread incorporation of in vitro absorption,
distribution, metabolism, and excretion (ADME) approaches into drug development by drug …

The superfamily of heme-thiolate proteins known as the cytochromes P450 is responsible for
the oxidative metabolism of the majority of drugs. Thus, the phenotypes of individuals with …

… TAM has three ring aromatic features in its molecular structure, whereas the benzodiazepines
and DTZ each have two. The similar orientation of the ring aromatic features of these …

ABBREVIATIONS: 2-OH olanzapine, 2-hydroxy methyl olanzapine; NO olanzapine, 4-N-oxide
olanzapine; NdM olanzapine, 4’-N-desmethyl olanzapine; 7-OH olanzapine, 7-hydroxy …

… Further metabolism of R-95913 yields a ring-opened form, R-138727 (Fig. 1) (Sugidachi et
al., 2000, 2001), which has two chiral centers and is actually a mixture of four stereoisomers …

The objective of this study is to assess the effectiveness of physiologically based
pharmacokinetic (PBPK) models for simulating human plasma concentration–time profiles for the …

The objective of this study was to evaluate the performance of various allometric and in vitro–in
vivo extrapolation (IVIVE) methodologies with and without plasma protein binding …

… with the pricing analysis developed by Ring, recast here as minimum-uplift pricing, provides
an alternative equilibrium approach.A few conclusions emerge: • The IP formulation of the …

Studies were performed to determine the human enzymes responsible for the biotransformation
of atomoxetine to its major metabolite, 4-hydroxyatomoxetine, and to a minor metabolite,…