Pharmacogenetics of paraoxonases: a brief review

DI Draganov, BN La Du - Naunyn-Schmiedeberg's archives of …, 2004 - Springer
… Teiber, BN La Du, unpublished data). Since lactones are common constituents of plants,
and are natural flavoring agents in many food products, lactonase activity may represent an …

Biochemical, pathologic and clinical aspects of alcaptonuria, ochronosis and ochronotic arthropathy: review of world literature (1584–1962)

WM O'brien, BN La Du, JJ Bunim - The American Journal of Medicine, 1963 - Elsevier
The biomedical literature on alcaptonuria, ochronosis and ochronotic joint disease, including
604 cases reported from thirty-five countries, is reviewed. The history of the development of …

Current progress on esterases: from molecular structure to function

…, SP Sanghani, M Hosokawa, BN La Du - Drug Metabolism and …, 2002 - ASPET
This article reports on a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. …

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

…, JA Berliner, SY Hama, BN La Du… - The Journal of …, 1995 - Am Soc Clin Investig
Our group has previously demonstrated that oxidized phospholipids in mildly oxidized LDL (MM-LDL)
produced by oxidation with lipoxygenase, iron, or cocultures of artery wall cells …

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

…, SL Primo-Parmo, BN La Du - The Journal of …, 1998 - Am Soc Clin Investig
… Kuo, CL, and BN La Du. 1995. Comparison of purified … Smolen, HW Eckerson, and BN
La Du. 1991. Purification of … Wyte, and BN La Du. 1983. The human serum paraoxonase …

Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell …

…, TM McIntyre, SM Prescott, BN La Du… - The Journal of …, 1995 - Am Soc Clin Investig
We previously reported that high density lipoprotein (HDL) protects against the oxidative
modification of low density lipoprotein (LDL) induced by artery wall cells causing these cells to …

The human serum paraoxonase/arylesterase polymorphism.

HW Eckerson, CM Wyte, BN La Du - American journal of human …, 1983 - ncbi.nlm.nih.gov
… A preliminary report of this work has been presented (ECKERSON HW, WYTE CM, LA
Du BN: Pharmacogenetic studies on human serum paraoxonase: relative paraoxonase/…

The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family

SL Primo-Parmo, RC Sorenson, J Teiber, BN La Du - Genomics, 1996 - Elsevier
… ridge, O., and La Du, BN (1995a). Reconsideration of the catalytic … , Sorenson, RC,
Primo-Parmo, SL, Camper, SA, and La Du, … Protective effect of BN (1995b). The genetic mapping …

[HTML][HTML] Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

…, A Speelman, Y Osawa, R Sunahara, BN La Du - Journal of lipid …, 2005 - ASBMB
The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and
PON3. Their physiological role(s) and natural substrates are uncertain. We developed a …

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.

KN Gan, A Smolen, HW Eckerson, BN La Du - Drug Metabolism and …, 1991 - ASPET
Evidence is presented that human serum contains a single enzyme with both paraoxonase
and arylesterase activities. Throughout the steps of purification and after obtaining over 600-…