Background Mutations in hedgehog pathway genes, primarily genes encoding patched
homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a …

Purpose Apoptosis ligand 2/tumor necrosis factor–related apoptosis-inducing ligand (Apo2L/TRAIL)—a
member of the tumor necrosis factor cytokine family—induces apoptosis by …

Intrinsic and acquired multidrug resistance (MDR) in many human cancers may be due to
expression of the multidrug transporter P-glycoprotein (Pgp), which is encoded by the mdr1 …

Objective Our objective was to assess the pharmacokinetics of erlotinib in a large patient
population with solid tumors, identify covariates, and explore relationships between exposure …

Metabolism and excretion of erlotinib, an orally active inhibitor of epidermal growth factor
receptor tyrosine kinase, were studied in healthy male volunteers after a single oral dose of [ 14 …

Forty-two evaluable endomyocardial biopsies were obtained from 29 patients treated with
epirubicin, the 4′-epimer of doxorubicin in cumulative doses ranging from 147 mg/m 2 to 888 …

… Gosland MP, Lum BL, Sikic BI: Reversal by cefoperazone of resistance to etoposide,
doxorubicin, and vinblastine in multidrug resistant human sarcoma cells. Cancer Res 49:6901-6905…

Acid-reducing agents (ARAs) are the most commonly prescribed medications in North America
and Western Europe. There are currently no data describing the prevalence of their use …

In multidrug resistance, the MDR1 gene product, P-glycoprotein (P-gp) is thought to function
as an efflux transport pump with broad specificity for a variety of anticancer drugs. The …

Purpose: To study the effects of cyclosporine (CsA), a moulator of multidrug resistance (MDR),
on the pharmacokinetics and toxicities of doxorubicin. Patients and Methods: Nineteen …